147124-37-6

Basic information

• Product Name: Methyl 2-(4-chloro-2-nitrophenyl)acetate
• Synonyms: Methyl 2-(4-chloro-2-nitrophenyl)acetate;METHYL 2-(4-CHLORO-2-NITROPHENYL)ACETATE（WS203961）
• CAS NO: 147124-37-6
• Molecular Formula: C₉H₈ClNO₄
• Molecular Weight: 229.61712
• Mol File: 147124-37-6.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 303.984°C at 760 mmHg
• Flash Point: 137.645°C
• Appearance: /
• Density: 1.383g/cm³
• Vapor Pressure: 0.001mmHg at 25°C
• Refractive Index: 1.56
• Storage Temp.: 2-8°C
• CAS DataBase Reference: Methyl 2-(4-chloro-2-nitrophenyl)acetate(CAS DataBase Reference)
• NIST Chemistry Reference: Methyl 2-(4-chloro-2-nitrophenyl)acetate(147124-37-6)
• EPA Substance Registry System: Methyl 2-(4-chloro-2-nitrophenyl)acetate(147124-37-6)

Safety Data

• Hazardous Substances Data: 147124-37-6(Hazardous Substances Data)

Usage

General Description

Methyl 2-(4-chloro-2-nitrophenyl)acetate is a chemical compound with the molecular formula C9H8ClNO4. It is a yellow solid at room temperature and is commonly used in the synthesis of pharmaceuticals and agrochemicals. Methyl 2-(4-chloro-2-nitrophenyl)acetate is an ester of methyl and 2-(4-chloro-2-nitrophenyl)acetic acid, and it is often used as an intermediate in the production of various organic compounds. Its properties make it a versatile building block for the synthesis of a wide range of chemical compounds and it is commonly used in research and industrial applications.

InChI:InChI=1/C9H8ClNO4/c1-15-9(12)4-6-2-3-7(10)5-8(6)11(13)14/h2-3,5H,4H2,1H3

Upstream product

• 67-56-1 methanol 
• 107-13-1 acrylonitrile 
• 582305-49-5 2-(4-chloro-2-nitro-phenyl)-malonic acid dimethyl ester 
• 89-61-2 2,5-dichloronitrobenzene 
• 147124-32-1 dimethyl (4-chloro-2-nitrophenyl)malonate 

Downstream Products

• 717134-46-8 (2-acetylamino-4-chloro-phenyl)-acetic acid methyl ester 
• 147371-91-3 Methyl (4-chloro-2-[N-hydroxyamino] phenyl)acetate 
• 56341-37-8 6-chloro-2-oxindole 

Relevant articles and documents

A Unified Catalytic Asymmetric (4+1) and (5+1) Annulation Strategy to Access Chiral Spirooxindole-Fused Oxacycles

A unified catalytic asymmetric (N+1) (N=4, 5) annulation reaction of oxindoles with bifunctional peroxides has been achieved in the presence of a chiral phase-transfer catalyst (PTC). This general strategy utilizes peroxides as unique bielectrophilic four- or five-atom synthons to participate in the C?C and the subsequent umpolung C?O bond-forming reactions with one-carbon unit nucleophiles, thus providing a distinct method to access the valuable chiral spirooxindole-tetrahydrofurans and -tetrahydropyrans with good yields and high enantioselectivities under mild conditions. DFT calculations were performed to rationalize the origin of high enantioselectivity. The gram-scale syntheses and synthetic utility of the resultant products were also demonstrated.

AMINOMETHYL-BIARYL DERIVATIVES AS COMPLEMENT FACTOR D INHIBITORS AND USES THEREOF

The present invention provides a compound of formula (I), a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical com

A general oxindole synthesis

A general synthesis of indol-2(3H)-ones (oxindoles), was developed based on the addition of dimethyl malonate to commercially available halonitrobenzenes. The advantage of this route over many other oxindole syntheses was the regiochemical control of the substitution pattern on the aromatic ring.