147199-27-7Relevant academic research and scientific papers
18-Substituted steroids. Part 18. Chemical synthesis and mineralocorticoid activity of 2α- and 2β-hydroxyaldosterone
Kirk, David N.,Schroeder, Martin H.,Latif, Syed A.,Souness, Graham W.,Morris, David J.
, p. 59 - 63 (1993)
The 2α-hydroxy and 2β-hydroxy derivatives of aldosterone have been synthesized chemically from aldosterone, after the earlier identification of 2α-hydroxylated metabolites formed in liver.Both 2α- and 2β-hydroxyaldosterone are potent mineralocorticoids, with activities on the order of 1/10 that of aldosterone on the basis of a rat bioassay. Keywords: steroids; 2α-hydroxyaldosterone; 2β-hydroxyaldosterone; mineralocorticoid activity; liver metabolism
