147200-08-6

Upstream product

• 147200-10-0 (3S,5R)-dihydro-5-hydroxymethyl-3-methyl-2(3H)-furanone 
• 58479-61-1 tert-butylchlorodiphenylsilane 
• 107033-46-5 (R)-(tert-butyldiphenylsilyloxy)methyloxirane 
• 6893-26-1 D-Glutamic acid 
• 52813-63-5 (5R)-2,3,4,5-tetrahydro-5-hydroxymethyl-2-furanone 
• 53558-93-3 (R)-tetrahydro-5-oxo-2-furancarboxylic acid 
• 115362-50-0 (3S,5R)-4,5-dihydro-5-iodomethyl-3-methyl-2(3H)-furanone 
• 128075-94-5 (R)-5-{[(tert-butyldiphenylsilyl)oxy]methyl}dihydrofuran-2(3H)-one 
• 74-88-4 methyl iodide 
• 114142-19-7 S-γ-tert-butyldiphenylsilyloxymethyl-γ-butyrolactone 

Downstream Products

• 890027-35-7 (3S,5R)-5-(tert-butyldiphenylsilanyloxymethyl)-2-[(E)-(3S)-3-methoxymethoxymethyl-3-methyl-6-trimethylsilanyl-hex-4-enyl]-3-methyltetrahydrofuran-2-ol 
• 123827-81-6 (2R,4S,5R)-1-(tert-Butyl-diphenyl-silanyloxy)-4-methyl-hexane-2,5-diol 
• 123827-81-6 (2R,4S,5S)-1-(tert-Butyl-diphenyl-silanyloxy)-4-methyl-hexane-2,5-diol 
• 123827-81-6 (2R,4R,5R)-1-(tert-Butyl-diphenyl-silanyloxy)-4-methyl-hexane-2,5-diol 
• 123827-81-6 (2R,4R,5S)-1-(tert-Butyl-diphenyl-silanyloxy)-4-methyl-hexane-2,5-diol 
• 890028-20-3 (+)-tert-butyl-[(2R,4S,5R,6R,7S)-7-methoxymethoxymethyl-4,7-dimethyl-6-vinyl-1-oxaspiro[4.4]non-2-ylmethoxy]diphenylsilane 
• 1344673-74-0 2-[(2R,4S,5S,6R,7R)-7-[(E)-((2S,3S)-2-tert-butyldimethylsilyloxymethyl-3-tert-butyldiphenylsilyloxy-5-oxocyclopentylidene)methyl]-2-tert-butyldiphenylsilyloxymethyl-4,7-dimethyl-1-oxaspiro[4.4]non-6-yl]ethyl 2,2-dimethylpropanoate 
• 1344673-77-3 2-[(2R,4S,5S,6R,7S)-7-[(R)-((1S,2S,3S)-2-tert-butyldimethylsilyloxymethyl-3-tert-butyldiphenylsilyloxy-5-oxocyclopentyl)(hydroxy)methyl]-2-tert-butyldiphenylsilyloxymethyl-4,7-dimethyl-1-oxaspiro[4.4]non-6-yl]ethyl 2,2-dimethylpropanoate 
• 1344673-75-1 2-[(2R,4S,5S,6R,7S)-2-tert-butyldiphenylsilyloxymethyl-7-formyl-4,7-dimethyl-1-oxaspiro[4.4]non-6-yl]ethyl pivalate 
• 1344673-84-2 2-[(2R,4S,5S,6R,7S)-2-tert-butyldiphenylsilyloxymethyl-7-hydroxymethyl-4,7-dimethyl-1-oxaspiro[4.4]non-6-yl]ethyl pivalate 
• 1344673-83-1 2-{(2R,4S,5S,6R,7S)-2-tert-butyldiphenylsilyloxymethyl-7-methoxymethoxymethyl-4,7-dimethyl-1-oxaspiro[4.4]non-6-yl}ethyl pivalate 
• 890027-31-3 (-)-tert-butyl-[(2R,4S,5S,6R,7S)-7-methoxymethoxymethyl-4,7-dimethyl-6-vinyl-1-oxaspiro[4.4]non-2-ylmethoxy]diphenylsilane 
• 890028-22-5 (-)-tert-butyl-[(2R,4S,5S,6S,7S)-7-methoxymethoxymethyl-4,7-dimethyl-6-vinyl-1-oxaspiro[4.4]non-2-ylmethoxy]diphenylsilane 
• 128440-18-6 (3R,5R)-5-(tert-butyldiphenylsilyloxymethyl)-3-methyl-dihydrofuran-2(3H)-one 

Relevant academic research and scientific papers

Design, synthesis, and cytotoxicity of stabilized mycolactone analogs

On exposure to visible light, mycolactone A/B, the causative toxin of Buruli ulcer, rearranges to a mixture of four photo-mycolactones apparently via a rare photochemically-induced [4πs?+?2πa] cycloaddition. In

Enantioselective total synthesis of (+)-ophiobolin A

The enantioselective total synthesis of (+)-ophiobolin A is described. This total synthesis features the construction of the spiro CD ring of (+)-ophiobolin A through a stereoselective intramolecular Hosomi-Sakurai cyclization reaction, the joining of the

Synthetic studies on (+)-ophiobolin A: Asymmetric synthesis of the spirocyclic CD-ring moiety

Asymmetric synthesis of the spirocyclic CD-ring moiety of (+)-ophiobolin A is described. Fragment A, which was prepared via pig liver esterase (PLE)-mediated kinetic resolution, and fragment B, which was prepared via diastereoselective allylation and subs

Stereoselective synthesis of a C19-C26 fragment of amphidinolides G and H

A short, stereoselective synthesis of the C19-C26 segment of the structure of the cytotoxic macrolides amphidinolides G and H is reported. A precursor from the chiral pool has been used as the starting material.

Synthetic studies of zoanthamine/norzoanthamine alkaloids: Advanced intermediate for the heterocyclic aminal core

An advanced intermediate for the heterocyclic aminal core of zoanthamine/norzoanthamine alkaloids was prepared in an enantio and stereoselective manner. Contiguous quaternary chiral centers were selectively constructed utilizing a stereoselective cuprate addition to the readily available (+)-Wieland-Miescher ketone.

Enantiopure DAVA-Derivatives-Part III. Synthesis of All 4 Stereoisomers of 2-Methyl-4-hydroxy-5-aminopentanoic Acid (2-Me-4-OH-DAVA)

A stereoselective synthesis of the 4 stereoisomers of 2-methyl-4-hydroxy-5-amino-pentanoic acid namely 2R,4S-9a, 2S,4S-9b, ent-9a and ent-9b is presented, starting from the known lactones S-1 and R-1, which are readily avalaible from L- and D-glutamic acid.Only ent-9b shows affinity for GABAB-receptors sites.

Lactols in Stereoselection 3. Highly anti-Cram Selective 1,2-Asymmetric Induction

Nucleophilic addition of MeTi(O-iPr)3 to α-chiral lactols proceeds in highly diastereoselective manner.The sense of the diastereofacial selection is anti-Cram-type, which provides a new and useful method for 1,2-asymmetric induction.