147221-38-3Relevant academic research and scientific papers
2-Phenyl isopropyl esters as carboxyl terminus protecting groups in the fast synthesis of peptide fragments
Yue,Thierry,Potier
, p. 323 - 326 (1993)
The esters of Fmoc aminoacids derived from 2-phenylisopropanol have been prepared by using 2-phenylisopropyltrichloroacetimidate 1. They prevent diketopiperazine formation during amino deprotection of dipeptides and can be cleaved in the presence of Boc and O-Bu(t). They are thus well suited for the protection of C-terminus when a fmoc strategy is used to build up peptide fragments.
2-Phenyl isopropyl and t-butyl trichloroacetimidates: Useful reagents for ester preparation of N-protected amino acids under neutral conditions
Thierry, Josiane,Yue, Chongwei,Potier, Pierre
, p. 1557 - 1560 (2007/10/03)
2-Phenylisopropyl and t-butyl trichloroacetamidates 1 and 2 are useful reagents for the esterification of N-protected aminoacids under mild neutral conditions. In the case of hydroxyl-containing amino acids dialkylation occurs but no selectivity could be obtained.
