2-Phenyl isopropyl esters as carboxyl terminus protecting groups in the fast synthesis of peptide fragments

Article abstract of DOI:10.1016/S0040-4039(00)60578-6

The esters of Fmoc aminoacids derived from 2-phenylisopropanol have been prepared by using 2-phenylisopropyltrichloroacetimidate 1. They prevent diketopiperazine formation during amino deprotection of dipeptides and can be cleaved in the presence of Boc and O-Bu(t). They are thus well suited for the protection of C-terminus when a fmoc strategy is used to build up peptide fragments.