147248-13-3Relevant academic research and scientific papers
Transition-metal free N-arylation of cyanamides by diaryliodonium triflates in aqueous media
Li, Jihui,Zheng, Xinyi,Li, Wei,Zhou, Wei,Zhu, Wen,Zhang, Yucang
, p. 77 - 80 (2016/01/12)
An operationally simple protocol is established for the synthesis of disubstituted cyanamides through the transition-metal free N-arylation of cyanamides by diaryliodonium triflates in aqueous media. Both alkyl and aryl cyanamides are well compatible with the mild reaction conditions. The one-pot synthesis of ureas is also possible through sequential arylation and hydrolysis of cyanamides, diaryliodonium triflates and H2O with good yields.
N-SUBSTITUTED HETEROCYCLIC DERIVATIVES USEFUL IN THE TREATMENT OF CARDIOVASCULAR DISORDERS
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, (2008/06/13)
The present invention relates to N-substituted heterocyclic derivatives of formula: STR1 processes for their preparation, and pharmaceutical compositions which contain them. The compounds according to the invention are non-peptide compounds which oppose the action of angiotensin II. The compounds according to the invention are thus useful in the treatment of cardiovascular disorders such as hypertension and heart failure.
