147253-56-3

Upstream product

• 169104-86-3 (3AS,7AS)-7,7-diphenyl-perhydroisoindol-4-one hydrochloride 
• 24424-99-5 di-tert-butyl dicarbonate 
• 144-55-8 sodium hydrogencarbonate 
• 77-92-9 citric acid 

Downstream Products

• 153438-77-8 (3AS,4S,7AS)-7,7-diphenyl-4-(2-methoxyphenyl)-2-(tert-butoxycarbonyl)perhydroisoindol-4-ol 

Relevant academic research and scientific papers

Synergizing combination having an antagonist effect on NKI and NK2 receptors

Synergising associations characterized in that they are comprised of at least one product having an antagonist activity on NK1 receptors and at least one product having an antagonist activity on NK2 receptors. Said associations are useful in the treatment

Perhydroisoindole derivatives as antagonists of substance P

This invention relates to novel perhydroisoindole derivatives of general formula (I), STR1 wherein radicals R are phenyl radicals optionally 2- or 3-substituted by a halogen atom or a methyl radical; R 1 is optionally substituted phenyl, cyclohexadienyl, naphthyl, indenyl or optionally substituted heterocyclyl; R 2 is H, halogen, OH, alkyl, aminoalkyl, alkylaminoalkyl, dialkylaminoalkyl, alkyloxy, alkylthio, acyloxy, carboxy, optionally substituted alkyloxycarbonyl, benzyloxycarbonyl, amino or acylamino; R 3 is optionally 2-substituted phenyl; R 4 is OH or fluorine when R 5 is H, or R 4 and R 5 are OH or R 4 and R 5 together form a bond; isomeric forms and mixtures thereof; optionally salts thereof where applicable; and preparation thereof. The novel derivatives are particularly useful as P substance antagonists.