1472655-89-2Relevant academic research and scientific papers
New convenient approach for the synthesis of benzyl 2H-chromenones and their α-amylase inhibitory, ABTS+ scavenging activities
Kumar, Jaladi Ashok,Tiwari, Ashok Kumar,Saidachary, Gannerla,Kumar, Domati Anand,Ali, Zehra,Sridhar, Balasubramanian,Raju, Bhimapaka China
, p. 806 - 811 (2013/09/23)
Series of new benzyl 2H-chromenones 6a-n was synthesized by Pechmann condensation of substituted benzyl resorcinols 2a-c and 3a with various β-ketoesters such as ethyl 3-oxobutanoate, ethyl 3-oxo-3-phenylpropanoate, ethyl 4-chloro-3-oxobutanoate, ethyl 4,4,4-trifluoro-3-oxobutanoate and ethyl 2-chloro-3-oxobutanoate 5a-e in very good yields. Synthesized compounds 6a-n were screened for their α-amylase inhibitory, and ABTS+ scavenging activities. In the present series of compounds, compound 8-benzyl-7-hydroxy-4-phenyl-2H-chromen-2-one 6c and 8-benzyl-7-hydroxy-4-methyl- 2H-chromen-2-one 6a were most potent ABTS+ radical scavenging and α-amylase inhibitor. Although compound 6,8-dibenzyl-7-hydroxy-4- (trifluoromethyl)-2H-chromen-2-one 6h displayed potent ABTS+ free radical scavenging potential, it was found poor in inhibiting pancreatic α-amylase.
