147283-76-9

Basic information

• Product Name: ETHYL (3-NITRO-2-OXO-1,2-DIHYDROPYRIDYL)ACETATE
• Synonyms: ETHYL (3-NITRO-2-OXO-1,2-DIHYDROPYRIDYL)ACETATE;(3-Nitro-2-oxo-2H-pyridin-1-yl)-acetic acid ethyl ester
• CAS NO: 147283-76-9
• Molecular Formula: C₉H₁₀N₂O₅
• Molecular Weight: 226.19
• Mol File: 147283-76-9.mol
• Article Data: 10

Chemical Properties

• Melting Point: 54-56 °C
• Boiling Point: 394.9±42.0 °C(Predicted)
• Appearance: /
• Density: 1.37±0.1 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: -5.65±0.70(Predicted)
• CAS DataBase Reference: ETHYL (3-NITRO-2-OXO-1,2-DIHYDROPYRIDYL)ACETATE(CAS DataBase Reference)
• NIST Chemistry Reference: ETHYL (3-NITRO-2-OXO-1,2-DIHYDROPYRIDYL)ACETATE(147283-76-9)
• EPA Substance Registry System: ETHYL (3-NITRO-2-OXO-1,2-DIHYDROPYRIDYL)ACETATE(147283-76-9)

Safety Data

• Hazardous Substances Data: 147283-76-9(Hazardous Substances Data)

Usage

General Description

ETHYL (3-NITRO-2-OXO-1,2-DIHYDROPYRIDYL)ACETATE is a chemical compound with the molecular formula C9H9NO5. It is a yellow solid that is commonly used as an intermediate in the synthesis of pharmaceuticals, agrochemicals, and other organic compounds. ETHYL (3-NITRO-2-OXO-1,2-DIHYDROPYRIDYL)ACETATE is also known by its trade name Ethyl 3-nitro-2-oxo-1,2-dihydropyridylacetate. It is used as a building block in organic synthesis and can undergo various chemical reactions to produce a wide range of derivatives. ETHYL (3-NITRO-2-OXO-1,2-DIHYDROPYRIDYL)ACETATE is primarily used in the manufacturing of medicines and is also employed in the production of various other chemical products.

Upstream product

• 6332-56-5 3-nitropyridone 
• 623-48-3 ethyl iodoacetae 
• 6332-56-5 2-hydroxy-3-nitropyridine 
• 105-36-2 ethyl bromoacetate 

Downstream Products

• 179524-91-5 [3-(3-methoxy-benzenesulfonylamino)-2-oxo-2H-pyridin-1-yl]-acetic acid ethyl ester 
• 369384-19-0 [3-(3-methoxy-benzenesulfonylamino)-2-oxo-2H-pyridin-1-yl]-acetic acid 
• 206352-84-3 C₃₀H₃₃N₇O₇S₃ 
• 179523-52-5 ethyl (3-[(benzylsulfonyl)amino]-2-oxo-1,2-dihydropyridyl)acetate 
• 179523-53-6 [3-[(benzylsulfonyl)amino]-2-oxo-1,2-dihydropyridyl]acetic acid 
• 147283-78-1 2-(3-nitro-2-oxopyridin-1(2H)-yl)acetic acid 
• 147283-74-7 ethyl 3-amino-2-oxo-1,2-dihydro-1-pyridylacetate 

Relevant articles and documents

A facile and efficient method for the synthesis of novel pyridone analogues by aminolysis of an ester under solvent-free conditions

A series of 15 pure novel N-alkylated pyridone derivatives have been synthesized in 73-96% yields on treatment of ethyl (2-pyridone)acetates with structurally diverse amines in an efficient aminolysis procedure under 'solvent-free' conditions.

Non-peptide αvβ3 antagonists. Part 6: Design and synthesis of αvβ3 antagonists containing a pyridone or pyrazinone central scaffold

Two novel series of small-molecule RGD mimetics containing either a substituted pyridone or pyrazinone central constraint were prepared. Modification of the β-alanine 3-substituent produced compounds that are potent and selective αvβ3 antagonists and exhibit a range of physicochemical properties.

Aromatic heterocyclic derivatives as enzyme inhibitors

The present invention discloses peptide aldehydes which are potent and specific inhibitors of thrombin, their pharmaceutically acceptable salts, pharmaceutically acceptable compositions thereof, and methods of using them as therapeutic agents for disease states in mammals characterized by abnormal thrombosis.