147295-36-1

Upstream product

• 116384-92-0 (4S,6R)-4-Methyl-4-p-tolyl-6-trimethylsilanyl-oxepan-2-one 
• 116384-93-1 (3S,5R)-6-Hydroxy-3-methyl-3-p-tolyl-5-trimethylsilanyl-hexanoic acid methyl ester 
• 116498-75-0 (3S,5R)-3-Methyl-3-p-tolyl-5-trimethylsilanyl-cyclohexanone 
• 122-00-9 para-methylacetophenone 
• 147295-33-8 Trimethyl-((R)-4-methyl-4-p-tolyl-cyclohex-1-enyloxy)-silane 
• 138371-75-2 4-methyl-4-para-tolylcyclohexanone 
• 138371-74-1 4-methyl-4-(p-tolyl)cyclohex-2-en-1-one 
• 33596-66-6 2-(4-methylphenyl)propanal 
• 36553-42-1 ethyl β-methyl-β-(p-methylphenyl)glycidate 
• 116384-94-2 (R)-3-Methyl-3-p-tolyl-hexanedioic acid dimethyl ester 

Downstream Products

• 86505-48-8 (R)-3-methyl-3-(p-tolyl)cyclopentan-1-one 

Relevant academic research and scientific papers

Construction of a Chiral Quaternary Carbon Center by Enantioselective Deprotonation: Application to the Formal Synthesis of (+)-α-Cuparenone

Construction of a chiral quaternary carbon center was achieved by employing an enantioselective deprotonation with chiral bases and this strategy was applied to the formal synthesis of (+)-α-cuparenone.

CONSTRUCTION OF CHIRAL QUARTERNARY CARBON CENTERS USING 3-SUBSTITUTED 5-TRIMETHYLSILYL-2-CYCLOHEXENONES: SYNTHESIS OF (+)-α-CUPARENONE

1,4-Addition of Grignard reagents to 3-substituted 5-trimethylsilyl-2-cyclohexenones proceeded in a highly diastereoselective manner.By utilizing the reaction, (+)-α-cuparenone was synthesized starting from enantiomerically pure 3-p-tolylthio-5-(trimethyl