33596-66-6

Basic information

• Product Name: 2-p-tolyl-propionaldehyde
• CAS NO: 33596-66-6
• Molecular Weight: 148.205
• Mol File: 33596-66-6.mol
• Article Data: 78

Chemical Properties

• CAS DataBase Reference: 2-p-tolyl-propionaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 2-p-tolyl-propionaldehyde(33596-66-6)
• EPA Substance Registry System: 2-p-tolyl-propionaldehyde(33596-66-6)

Safety Data

• Hazardous Substances Data: 33596-66-6(Hazardous Substances Data)

Upstream product

• 99-86-5 1-methyl-4-isopropyl-1,3-cyclohexadiene 
• 36553-42-1 ethyl β-methyl-β-(p-methylphenyl)glycidate 
• 88416-64-2 2-(4-methylphenyl)-1,2-propanediol 
• 138-86-3 limonene. 
• 622-97-9 1-ethenyl-4-methylbenzene 
• 201230-82-2 carbon monoxide 
• 42432-27-9 p-methyl-α-methylstyrene oxide 
• 7664-93-9 sulfuric acid 
• 1195-32-0 1-methyl-4-isopropenylbenzene 
• 66334-30-3 2(p-tolyl) 1-methoxy 1-propene 
• 624-31-7 4-tolyl iodide 
• 107-18-6 allyl alcohol 
• 64-18-6 formic acid 
• 33596-66-6 2-(4-methylphenyl)propanal 

Downstream Products

• 4371-50-0 para-cymen-9-ol 
• 99-72-9 2-p-tolyl-propionaldehyde 
• 2109-18-4 2-p-tolyl-propionaldehyde-semicarbazone 
• 938-94-3 (R,S)-2-(4'-methylphenyl) propionic acid 
• 84878-56-8 p-(2,2-dimethoxy-1-methylethyl)toluene 
• 145987-17-3 (E)-4-p-Tolyl-pent-2-enoic acid ethyl ester 
• 138371-74-1 4-methyl-4-(p-tolyl)cyclohex-2-en-1-one 
• 82632-53-9 4-p-Tolyl-pent-1-yn-3-ol 
• 99-94-5 p-Toluic acid 
• 108-88-3 toluene 
• 4395-75-9 2-(p-tolyl)propan-1-amine 
• 2114-40-1 2-bromo-1-(4-tolyl)-propane 

Relevant articles and documents

Synthesis of rac-ɑ-aryl propionaldehydes via branched-selective hydroformylation of terminal arylalkenes using water-soluble Rh-PNP catalyst

This work detailed the preparation of a class of water-soluble PNP ligands that differed by the nature of the substitute on phenyl ring of ligands. These ligands were incorporated into water-soluble rhodium-PNP complex catalysts that were used to regioselective hydroformylation of a series of terminal arylalkenes, providing efficient access to rac-α-aryl propionaldehydes in good to excellent yield (up to 97%) and branched-regioselectivity (up to 40:1 b/l ratio). Furthermore, gram-scale and diverse synthetic transformation demonstrated synthetic application of this methodology for non-steroidal antiinflammatory drugs.

Palladium-Catalyzed Allenamide Carbopalladation/Allylation with Active Methine Compounds

A palladium-catalyzed allenamide carbopalladation/allylation with active methine compounds has been developed. Various indoles and isoquinolinones bearing a quaternary carbon center were achieved with good efficiency, a broad substrate scope and good functional group tolerance. This reaction underwent cascade oxidative addition, carbopalladation, and allylic alkylation, and two new C-C bonds were formed in one pot.

Styrene Hydroformylation with In Situ Hydrogen: Regioselectivity Control by Coupling with the Low-Temperature Water–Gas Shift Reaction

The hydroformylation of olefins is one of the most important homogeneously catalyzed industrial reactions for aldehyde synthesis. Various ligands can be used to obtain the desired linear aldehydes in the hydroformylation of aliphatic olefins. However, in the hydroformylation of aromatic substrates, branched aldehydes are formed preferentially with common ligands. In this study, a novel approach to selectively obtain linear aldehydes in the hydroformylation of styrene and its derivatives was developed by coupling with a water–gas shift reaction on a Rh single-atom catalyst without the use of ligands. Detailed studies revealed that the hydrogen generated in situ from the water–gas shift is critical for the highly regioselective formation of linear products. The coupling of a traditional homogeneous catalytic process with a heterogeneous catalytic reaction to tune product selectivity may provide a new avenue for the heterogenization of homogenous catalytic processes.