147298-51-9Relevant academic research and scientific papers
Visible light-promoted synthesis of pyrrolidinone derivatives via Rose Bengal as a photoredox catalyst and their photophysical studies
Dutta, Arup,Rohman, Mostofa A.,Nongrum, Ridaphun,Thongni, Aiborlang,Mitra, Sivaprasad,Nongkhlaw, Rishanlang
supporting information, p. 8136 - 8148 (2021/05/21)
Herein, we report an intramolecular radical cyclization reaction towards the synthesis of pyrrolidinone derivatives via metal-free photoredox catalysis under irradiation from blue LEDs. Some of the remarkable features of this protocol include synthetic ef
A Br?nsted acid-catalyzed multicomponent reaction for the synthesis of highly functionalized γ-lactam derivatives
Corte, Xabier del,de Marigorta, Edorta Martinez,Palacios, Francisco,Vicario, Javier
, (2019/08/22)
Br?nsted acids catalyze a multicomponent reaction of benzaldehyde with amines and diethyl acetylenedicarboxylate to afford highly functionalized γ-lactam derivatives. The reaction consists of a Mannich reaction of an enamine to an imine, both generated in situ, promoted by a phosphoric acid catalyst and a subsequent intramolecular cyclization. The hydrolysis of the cyclic enamine substrate can provide enol derivatives and, moreover, a second attack of the amine on the carboxylate can afford amide derivatives. An optimization of the reaction conditions is presented in order to obtain selectively cyclic enamines that can afford the enol species after selective hydrolysis.
