14734-27-1

Upstream product

• 13057-53-9 [1-¹⁴C]benzyl alcohol 
• 591-50-4 iodobenzene 
• 51-90-1 [14C]carbon dioxide 
• 18615-08-2 [carboxyl-14C]-methyl benzoate 
• 24420-97-1 benzo[cyano-¹⁴C]nitrile 
• 690997-39-8 dibutyl(14C)formamide 
• 10425-64-6 <7-(14)C>-benzoyl chloride 

Relevant academic research and scientific papers

A convenient method for [14C]Carbonylation reactions

A simple, efficient method for generation of 14CO from Ba14CO3 has been developed. Reduction of 14CO2 using LiBEt3H gave [14C]formate in good yield which was treated with conc. H2SO4 to effect dehydration to 14CO. Through direct attachment of a reaction vessel containing aryl substrate and Pd(0) catalyst, [14C]carbonylation reactions were performed without the use of a mercury transfer pump. [14C]Carbonylation reactions using 14CO generated in this manner have been shown to proceed in good yield with a variety of substrates.

Use of dibutyl[14C]formamide as a formylating reagent in the Vilsmeier-Haack reaction and synthesis of a 14C-labeled novel phosphodiesterase-4 (PDE-4) inhibitor

A simple, high-yielding synthesis of dibutyl[14C]formamide ([14C]DBF; 1) from 14CO2 was developed (Scheme 1): reaction of LiBEt3H and 14CO2 followed by aqueous workup gave H14CO2H in high yield. Conversion of the [14C]formic acid to 1 was effected by a standard carbodiimide coupling procedure. The utility of 1 as an alternative to dimethyl[ 14C]formamide ([14C]DMF) in alkylation reactions and in the [14C]Vilsmeier-Haack reaction was demonstrated for several substrates (Table 2). A 14C-labeled phosphodiesterase-4 (PDE-4) inhibitor, [14C]-2, was synthesized by application of this technology (Scheme 2).

Synthesis of carbon-14 labelled 1,5 diaryl-[5- 14C]-1,2,3-triazolines

Two 1,2,3-triazoline anticonvulsants, 1-(4-methylsulphone-phenyl)-5-(4-methoxy-phenyl)-1,2,3-triazoline and 1-(4-methylsulphone-phenyl)-5-phenyl-1,2,3-triazoline, both labelled with carbon-14 in the 5-position, have been synthesized as part of a 5-step sequence. Copyright

Syntheses of N-t-butyl-α-phenylnitrone-α-14C and α-(4-pyridyl-1-oxide)-N-t-butylnitrone-α-14C

N-t-Butyl-α-phenylnitrone-α-14C was prepared from benzoic-α-14C acid via benzyl alcohol in 40 - 55% yield (sp. activity: 30 mCi/mmol). α-(4-Pyridyl-1-oxide)-N-t-butylnitrone-α-14C arrived from Ba14CO3

Atorvastatin, an HMG-CoA reductase inhibitor and efficient lipid-regulating agent. Part I. Synthesis of ring-labeled [14C]atorvastatin

Pyrrole-ring labeled [14C]atorvastatin (Lipitor, CI-981), [R-(R(*),R(*))]-2(4-fluorophenyl)-β,γ-dihydroxy-5-(1-methylethyl)-3-phenyl -4-[(phenylamino)-carbonyl]-1H-[3-14C]pyrrole-1-heptanoic acid calcium salt (2:1), was synthesized i

Synthesis of 6-chloro 2(-ethylamino)-4-methyl-4-phenyl-[-4-14c]-4h,- 3,1-benzoxazine (etifoxine)

Carbonation of phenyl lithium with 14CO2, followed by reduction of [14CO2] benzoic acid, led to [α-14C] benzyl alcohol 3, the oxidation of which afforded the [α-14C] benzaldehyde 4. The lat

Studies on the metabolism of propafenone. 1st comm.: Synthesis and chromatographic/mass spectrometric properties of the labelled compound and of the reference substances

The synthesis of 14C-propafenone and 2H-propafenone (propafenone: 2-(2'-hydroxy-3'-propylamino-propoxy)-ω-phenyl-propiophenone hydrochloride) and some reference compounds is described. The thin-layer chromatographic, high-performance liquid and gas chromatographic properties of the substances are described. Propafenone and the reference substances were studied by mass spectrometry and compared with each other, with respect to structural elucidation of the metabolites. The chromatographic and mass spectrometric data (key ions) enables the metabolites of propafenone to be identified in biological material.