147362-91-2Relevant articles and documents
On the metalation of 3-substituted and 3,6-disubstituted pyridazines
Turck, Alain,Ple, Nelly,Ndzi, Bruno,Queguiner, Guy,Haider, Norbert,Schuller, Herbert,Heinisch, Gottfried
, p. 599 - 606 (1993)
Metalation, pyradazines, lithiation Starting from 3,6-dichloropyridazine, a series of new pyridazines bearing lithiation-directing groups in α-position to a ring nitrogen atom (compounds 1-5) was prepared. Metalation employing lithium alkylamides was found to afford ortho-substituted pyridazines. The regioselectivity, depending on the nature of the metalating agent, is discussed.