Tetrahedron p. 599 - 606 (1993)
Update date:2022-07-30
Topics:
Turck, Alain
Ple, Nelly
Ndzi, Bruno
Queguiner, Guy
Haider, Norbert
Schuller, Herbert
Heinisch, Gottfried
Metalation, pyradazines, lithiation Starting from 3,6-dichloropyridazine, a series of new pyridazines bearing lithiation-directing groups in α-position to a ring nitrogen atom (compounds 1-5) was prepared. Metalation employing lithium alkylamides was found to afford ortho-substituted pyridazines. The regioselectivity, depending on the nature of the metalating agent, is discussed.
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Doi:10.1080/00397911.2013.800212
(2014)Doi:10.1016/S0040-4020(01)80339-2
(1993)Doi:10.1021/jo9711302
(1997)Doi:10.1021/jo00062a048
(1993)Doi:10.1016/j.jorganchem.2013.08.016
(2013)Doi:10.1039/c39930000424
(1993)
