On the metalation of 3-substituted and 3,6-disubstituted pyridazines

Article abstract of DOI:10.1016/S0040-4020(01)86263-3

Metalation, pyradazines, lithiation Starting from 3,6-dichloropyridazine, a series of new pyridazines bearing lithiation-directing groups in α-position to a ring nitrogen atom (compounds 1-5) was prepared. Metalation employing lithium alkylamides was found to afford ortho-substituted pyridazines. The regioselectivity, depending on the nature of the metalating agent, is discussed.