147372-97-2

Basic information

• Product Name: 6-FLUORO-3H-SPIRO[2-BENZOFURAN-1,4'-PIPERIDINE]
• Synonyms: 5-fluorospiro[1,3-dihydroisobenzofuran-3,4'-piperidine];6-fluoro-3H-spiro[isobenzofuran-1,4'-piperidine];5-fluorospiro[1H-isobenzofuran-3,4'-piperidine]
• CAS NO: 147372-97-2
• Molecular Formula: C12H14FNO
• Molecular Weight: 207.2440632
• Mol File: 147372-97-2.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 6-FLUORO-3H-SPIRO[2-BENZOFURAN-1,4'-PIPERIDINE](CAS DataBase Reference)
• NIST Chemistry Reference: 6-FLUORO-3H-SPIRO[2-BENZOFURAN-1,4'-PIPERIDINE](147372-97-2)
• EPA Substance Registry System: 6-FLUORO-3H-SPIRO[2-BENZOFURAN-1,4'-PIPERIDINE](147372-97-2)

Safety Data

• Hazardous Substances Data: 147372-97-2(Hazardous Substances Data)

Upstream product

• 229027-89-8 (2-bromo-4-fluorophenyl)methanol 
• 1006-41-3 2-bromo-4-fluorobenzoic acid 
• 845552-83-2 C₁₉H₂₂FNO₂ 
• 845552-82-1 1'-benzyl-6-fluoro-3H-spiro[2-benzofuran-1,4'-piperidine] 

Relevant articles and documents

SPIRO-5,6-DIHYDRO-4H-2,3,5,10B-TETRAAZA-BENZO[E]AZULENES

The present invention is concerned with spiro-dihydrotetraazabenzoazulenes, i.e. spiro-5,6-dihydro-4H-2,3,5,10b-tetraaza-benzo[e]azulenes of formula I wherein R1, R2, R3, X, Y, Z, m and n are as described herein. The compounds according to the invention act as V1a receptor modulators and are useful as therapeutics acting peripherally and centrally in the conditions of dysmenorrhea, male or female sexual dysfunction, hypertension, chronic heart failure, inappropriate secretion of vasopressin, liver cirrhosis, nephrotic syndrome, anxiety, depressive disorders, obsessive compulsive disorder, autistic spectrum disorders, schizophrenia, and aggressive behavior.

SPIROCYCLIC PIPERIDINES AS MCH1 ANTAGONISTS AND USES THEREOF

This invention is directed to compounds which are selective antagonists for melanin concentrating hormone-1 (MCH1) receptors. The invention provides a pharmaceutical composition comprising a therapeutically effective amount of the compound of the invention and a pharmaceutically acceptable carrier. This invention provides a pharmaceutical composition made by combining a therapeutically effective amount of the compound of this invention and a pharmaceutically acceptable carrier. This invention further provides a process for making a pharmaceutical composition comprising combining a therapeutically effective amount of the compound of the invention and a pharmaceutically acceptable carrier. This invention also provides a method of reducing the body mass of a subject which comprises administering to the subject an amount of a compound of the invention effective to reduce the body mass of the subject. This invention further provides a method of treating a subject suffering from depression and/or anxiety which comprises administering to the subject an amount of a compound of the invention effective to treat the subject=s depression and/or anxiety. This invention further provides a method of treating a subject suffering from a urinary disorder.