845552-82-1

Upstream product

• 229027-89-8 (2-bromo-4-fluorophenyl)methanol 
• 1006-41-3 2-bromo-4-fluorobenzoic acid 
• 1027149-82-1 1'-Benzyl-6-fluoro-3H-spiro[2-benzofuran-1,4'-piperidin]-3-one 
• 845552-83-2 C₁₉H₂₂FNO₂ 

Downstream Products

• 147372-97-2 6-fluoro-3H-spiro[2-benzofuran-1,4'-piperidine] 

Relevant academic research and scientific papers

SPIRO-5,6-DIHYDRO-4H-2,3,5,10B-TETRAAZA-BENZO[E]AZULENES

The present invention is concerned with spiro-dihydrotetraazabenzoazulenes, i.e. spiro-5,6-dihydro-4H-2,3,5,10b-tetraaza-benzo[e]azulenes of formula I wherein R1, R2, R3, X, Y, Z, m and n are as described herein. The compounds according to the invention act as V1a receptor modulators and are useful as therapeutics acting peripherally and centrally in the conditions of dysmenorrhea, male or female sexual dysfunction, hypertension, chronic heart failure, inappropriate secretion of vasopressin, liver cirrhosis, nephrotic syndrome, anxiety, depressive disorders, obsessive compulsive disorder, autistic spectrum disorders, schizophrenia, and aggressive behavior.

TETRAHYDROISOQUINOLINE OR ISOCHROMAN COMPOUNDS AS ORL-1 RECEPTOR LIGANDS FOR THE TREATMENT OF PAIN AND CNS DISORDERS

This invention provides the compounds of formula (I), or its a pharmaceutically acceptable ester or amide of such compound, or a pharmaceutically acceptable salt thereof, wherein X1 is NH; R1, R2, R4 through Rs