59868-79-0

Basic information

• Product Name: 1,3-Dihydroisobenzofuran-1β-ol
• Synonyms: 1,3-Dihydroisobenzofuran-1β-ol
• CAS NO: 59868-79-0
• Molecular Formula: C₈H₈O₂
• Molecular Weight: 136.14792
• Mol File: 59868-79-0.mol
• Article Data: 11

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1,3-Dihydroisobenzofuran-1β-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 1,3-Dihydroisobenzofuran-1β-ol(59868-79-0)
• EPA Substance Registry System: 1,3-Dihydroisobenzofuran-1β-ol(59868-79-0)

Safety Data

• Hazardous Substances Data: 59868-79-0(Hazardous Substances Data)

Usage

General Description

1,3-Dihydroisobenzofuran-1β-ol, also known as dihydrocarveol, is a bicyclic organic compound with a minty, camphor-like odor. It is a colorless liquid that is commonly used as a flavor and fragrance ingredient in various products such as toothpaste, mouthwash, and chewing gum. Dihydrocarveol is found naturally in spearmint and caraway essential oils, and it can also be synthesized through chemical processes. It is considered to be a relatively safe compound with low toxicity and is generally well tolerated by humans. Due to its pleasant odor and flavor, dihydrocarveol is widely used in the food and beverage industry as a flavoring agent. Additionally, it is also utilized in the production of perfumes and aromatherapy products.

Upstream product

• 201230-82-2 carbon monoxide 
• 5159-41-1 2-iodobenzyl alcohol 
• 496-14-0 1,3-dihydroisobenzofuran 
• 87-41-2 2-benzofuran-1(3H)-one 
• 612-14-6 phthalyl alcohol 
• 118-90-1 ortho-methylbenzoic acid 
• 524-38-9 N-hydroxyphthalimide 
• 10102-43-9 nitrogen(II) oxide 

Downstream Products

• 65539-67-5 1,3-dihydroisobenzofuranyl 2-formylbenzyl ether 
• 180713-44-4 2-[(pivaloyloxy)methyl]benzaldehyde 
• 643-79-8 o-phthalic dicarboxaldehyde 
• 1178871-16-3 (E)-3-(2-(hydroxymethyl)phenyl)-1-(thiophen-2-yl)prop-2-en-1-one 
• 216572-78-0 3-(2-hydroxymethylphenyl)acrylic acid methyl ester 
• 147377-67-1 (E)-ethyl 3-(2-(hydroxymethyl)phenyl)acrylate 
• 173912-31-7 (2-(2-methylprop-1-en-1-yl)phenyl)methanol 
• 81306-00-5 3-(tert-Butyl-dimethyl-silanyloxy)-3-[2-(tert-butyl-dimethyl-silanyloxymethyl)-phenyl]-propionaldehyde 

Relevant articles and documents

Squaramide-catalyzed asymmetric intramolecular oxa-michael reaction of α,β-unsaturated carbonyls containing benzyl alcohol: Construction of chiral 1-substituted phthalans

Organocatalytic enantioselective intramolecular oxa-Michael reactions of benzyl alcohol bearing α,β-unsaturated carbonyls as Michael acceptors are presented herein. Using cinchona squaramide-based organocatalyst, enones as well as α,βunsaturated esters containing benzyl alcohol provided their corresponding 1,3-dihydroisobenzofuranyl-1-methylene ketones and 1,3-dihydroisobenzofuranyl-1-methylene esters in excellent yields with high enantioselectivities. In addition, enantioenriched 1,3-dihydroisobenzofuranyl-1-methylene ketone could be obtained from the Wittig/oxa-Michael reaction cascade of 1,3-dihydro-2-benzofuran-1-ol.

6-membered pseudocyclic IBX acids: Syntheses, X-ray structural characterizations, and oxidation reactivities in common organic solvents

We designed and synthesized λ5-cyclic periodinanes 1 and 2, which are homologous to IBX (1-hydroxy-1-oxo-1H-1λ5- benzo[d][1,2]iodoxol-3-one) by one carbon, to thwart close packing of molecules in the crystal lattice to permit solubility in common organic solvents and to facilitate oxidations with enhanced reactivity. The X-ray crystal structures revealed that both 1 and 2 exist in the solid state as pseudocyclic (PC) acids, i.e., 1PC and 2PC, and that the molecules in the lattice are less weakly associated as compared to those in the parent IBX due to the twisting introduced via the sp3 benzylic carbon. Both 1PC and 2PC are found to dissolve in palpable amounts in DCM and acetonitrile to allow oxidation of a variety of alcohols and sulfides to carbonyl compounds and sulfoxides in a facile manner. The subtle differences in the sterics due to methyl and ethyl substituents in 1PC and 2PC are found to manifest in contrasting reactivities in that the oxidations of alcohols occur faster with 2PC, while those of sulfides to sulfoxides occur more rapidly with 1PC.

Preparation of Hydroperoxides by N-Hydroxyphthalimide-Catalyzed Aerobic Oxidation of Alkylbenzenes and Hydroaromatic Compounds and Its Application

An efficient approach to phenols and aldehydes through the formation of hydroperoxides from alkylbenzenes was successfully achieved by aerobic oxidation using N-hydroxyphthalimide (NHPI) as a catalyst. The oxidation of various alkylbenzenes with dioxygen by NHPI followed by treatment with a Lewis acid or triphenylphosphine led to phenols or aldehydes, respectively, in good yields. For example, the aerobic oxidation of cumene in the presence of a catalytic amount of NHPI at 75°C and subsequent treatment with H2SO4 gave phenol in 77% yield. 1,4-Dihydroxybenzene (61%) and 4-isopropylphenol (33%) were obtained from 1,4-diisopropylbenzene. On the other hand, dibenzyl ether was converted into phenol or benzaldehyde upon treatment of the resulting hydroperoxide with InCl3 or PPh3, respectively.