14743-95-4

Upstream product

• 14758-00-0 ethyl 6-(bromomethyl)-2-oxo-4-phenyl-1,2,3,4-tetrahydropyrimidine-5-carboxylate 
• 100-52-7 benzaldehyde 
• 123237-03-6 ethyl 6-methyl-4-phenyl-3,4-dihydropyrimidin-2(1H)-one-5-carboxylate 
• 263157-08-0 ethyl-6-(chloromethyl)-2-oxo-4-phenyl-1,2,3,4-tetrahydro-5-pyrimidinecarboxylate 

Relevant academic research and scientific papers

Metalation of Biginelli compounds. A general unprecedented route to C-6 functionalized 4-aryl-3,4-dihydropyrimidinones

4-Aryl-6-methyl-3,4-dihydro-2(1H)-pyrimidinone esters (DHPMs) readily undergo metalation at the C-6 methyl (vinylogous ester) position on treatment with lithium diisopropylamide at -10 °C. The resulting anion intermediates can be treated with electrophili

SYNTHESIS OF FUROPYRIMIDINE DERIVATIVES USING ETHYL 4-BROMOACETOACETATE

Reaction of ethyl 4-bromoacetoacetate (1) with benzaldehyde (2a) and urea in the presence of hydrochloric acid gave 6-bromomethyl-5-ethoxycarbonyl-4-phenyl-3,4-dihydro-2(1H)-pyrimidone (3a).Similarly, reaction of 1 and urea with p-anisaldehyde (2b), p-hyd