147492-93-1Relevant academic research and scientific papers
Irreversible inactivation of macrophage and brain nitric oxide synthase by L-N(G)-methylarginine requires NADPH-dependent hydroxylation
Feldman,Griffith,Hong,Stuehr
, p. 491 - 496 (1993)
L-N(G)-Methylarginine (NMA) is an established mechanism-based inactivator of murine macrophage nitric oxide synthase (mNOS). In this report, NMA is shown to irreversibly inhibit both mNOS (k(inact) = 0.08 min-1) and the recombinant constitutive
