Irreversible inactivation of macrophage and brain nitric oxide synthase by L-N(G)-methylarginine requires NADPH-dependent hydroxylation

DOI: 10.1021/jm00056a009

Source and publish data:

Journal of Medicinal Chemistry p. 491 - 496 (1993)

Update date:2022-08-04

Topics:

Authors:

Feldman Feldman

Griffith

Hong Hong

Stuehr Stuehr

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Article abstract of DOI:10.1021/jm00056a009

L-N(G)-Methylarginine (NMA) is an established mechanism-based inactivator of murine macrophage nitric oxide synthase (mNOS). In this report, NMA is shown to irreversibly inhibit both mNOS (k(inact) = 0.08 min^-1) and the recombinant constitutive

Full text of DOI:10.1021/jm00056a009

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