147501-26-6

Basic information

• Product Name: 3-OXO-3-O-TOLYL-PROPIONIC ACID METHYL ESTER
• Synonyms: 3-OXO-3-O-TOLYL-PROPIONIC ACID METHYL ESTER;3-OXO-3-(2-TOLYL)PROPIONIC ACID METHYL ESTER;2-METHYL-BETA-OXO-BENZENEPROPANOIC ACID METHYL ESTER;methyl 3-methylphenyl-3-oxopropanoate;methyl 3-oxo-3-o-tolylpropanoate;Methyl 2-methyl-b-oxo-benzenepropanoate;Methyl 3-(2-methylphenyl)-3-oxopropanoate
• CAS NO: 147501-26-6
• Molecular Formula: C₁₁H₁₂O₃
• Molecular Weight: 192.21
• Mol File: 147501-26-6.mol
• Article Data: 15

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3-OXO-3-O-TOLYL-PROPIONIC ACID METHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 3-OXO-3-O-TOLYL-PROPIONIC ACID METHYL ESTER(147501-26-6)
• EPA Substance Registry System: 3-OXO-3-O-TOLYL-PROPIONIC ACID METHYL ESTER(147501-26-6)

Safety Data

• Hazardous Substances Data: 147501-26-6(Hazardous Substances Data)

Usage

General Description

3-OXO-3-O-TOLYL-PROPIONIC ACID METHYL ESTER is a chemical compound with the molecular formula C11H12O3. It is an ester derivative of 3-oxo-3-phenylpropionic acid and belongs to the class of aromatic ketones. 3-OXO-3-O-TOLYL-PROPIONIC ACID METHYL ESTER is commonly used in organic synthesis as a reagent for forming carbon-carbon bonds and as a precursor for the production of various pharmaceuticals, agrochemicals, and fragrance compounds. It is also known for its potential anti-inflammatory and analgesic properties, making it a subject of interest in the pharmaceutical industry. However, it is important to handle and use this chemical with caution due to its potential health and environmental hazards.

Upstream product

• 933-88-0 ortho-toluoyl chloride 
• 95-46-5 2-methylphenyl bromide 
• 616-38-6 carbonic acid dimethyl ester 
• 577-16-2 2-Methylacetophenone 
• 529-20-4 2-methylphenyl aldehyde 
• 5788-17-0 methyl (2E)-3-methoxy-2-propenoate 
• 124393-57-3 methyl 3-hydroxy-3-(2-methylphenyl)propionate 

Downstream Products

• 654061-88-8 3-amino-3-(2-methylphenyl)acrylic acid methyl ester 
• 147499-01-2 (E)-ethyl 3-ethoxy-3-(2-methylphenyl)prop-2-enoate 
• 1173710-79-6 methyl (2Z)-3-(dimethylamino)-2-(2-methylbenzoyl)acrylate 
• 1245606-58-9 (Z)-3-methoxy-3-oxo-1-o-tolylprop-1-en-1-amine hydrochloride 
• 1426899-79-7 3-(5-bromo-2-fluoro-phenyl)-1-o-tolyl-propan-1-one 
• 40009-78-7 3-oxo-3-(o-tolyl)propanoic acid 
• 7517-82-0 methyl 3-(2-methylphenyl)-2-propynoate 

Relevant articles and documents

Palladium-Catalyzed Enantioselective Narasaka–Heck Reaction/Direct C?H Alkylation of Arenes: Iminoarylation of Alkenes

A palladium-catalyzed reaction of γ,δ-unsaturated oxime esters with oxadiazoles afforded dihydropyrroles in good to excellent yields through an intramolecular iminopalladation/intermolecular direct heteroarene C?H alkylation cascade. This unprecedented iminoarylation of alkenes was subsequently realized in an enantioselective manner in the presence of a chiral bidentate phosphine ligand (Synphos).

Enantioselective decarboxylative Mannich reaction of β-keto acids withC-alkynylN-BocN,O-acetals: access to chiral β-keto propargylamines

The chiral keto-substituted propargylamines are an essential class of multifunctional compounds in the field of organic and pharmaceutical synthesis and have attracted considerable attention, but the related synthetic approaches remain limited. Therefore, a concise and efficient method for the enantioselective synthesis of β-keto propargylaminesviachiral phosphoric acid-catalyzed asymmetric Mannich reaction between β-keto acids andC-alkynylN-BocN,O-acetals as easily availableC-alkynyl imine precursors has been demonstrated here, affording a broad scope of β-ketoN-Boc-propargylamines in high yields (up to 97%) with generally high enantioselectivities (up to 97?:?3 er).

Iron-catalysed 1,2-acyl migration of tertiary α-azido ketones and 2-azido-1,3-dicarbonyl compounds

Iron-catalysed 1,2-acyl migration of tertiary α-azido ketones and 2-azido-1,3-dicarbonyl compounds provides a simple and atom-economical approach toward enamides and isoquinolones. This paper reports two catalyst systems for these transformations which employ iron(ii) complexes [Fe(dpbz)]Br2 (dpbz = 1,2-bis(diphenylphosphino)benzene) and FeBr2/Et3N, respectively. [Fe(dpbz)]Br2 was found to be highly effective at converting 2-azido-2,3-dihydro-1H-inden-1-ones to isoquinolones. The reagent combination of FeBr2/Et3N, on the other hand, exhibited a broader catalytic scope, owing to the beneficial effect of Et3N. This latter catalyst system enables 2-azido-2-methyl-1,3-dicarbonyl compounds to be converted to the corresponding enamides under mild conditions in good yields.