5788-17-0

Basic information

• Product Name: METHYL 3-METHOXYACRYLATE
• Synonyms: Methyl trans-3-methoxyacrylate,95%;Methyl 3-methoxyacrylate;(E)-Methyl 3-Methoxyacrylate;Methyl trans-3-Methoxyacrylate 97%;Methyl trans-3-methoxyacrylate;2-Propenoic acid,3-methoxy-, methyl ester, (2E)-;trans-3-methoxyacrylate;METHYL TRANS-3-METHOXYACRYLATE
• CAS NO: 5788-17-0
• Molecular Formula: C₅H₈O₃
• Molecular Weight: 116.12
• EINECS: 412-900-4
• Product Categories: C2 to C5;Carbonyl Compounds;Esters
• Mol File: 5788-17-0.mol
• Article Data: 5

Chemical Properties

• Melting Point: 3-4 °C
• Boiling Point: 56 °C18 mm Hg(lit.)
• Flash Point: 145 °F
• Appearance: /
• Density: 1.08 g/mL at 25 °C(lit.)
• Vapor Pressure: 3.05mmHg at 25°C
• Refractive Index: n20/D 1.451(lit.)
• Storage Temp.: 2-8°C
• CAS DataBase Reference: METHYL 3-METHOXYACRYLATE(CAS DataBase Reference)
• NIST Chemistry Reference: METHYL 3-METHOXYACRYLATE(5788-17-0)
• EPA Substance Registry System: METHYL 3-METHOXYACRYLATE(5788-17-0)

Safety Data

• Hazard Codes: Xi
• Statements: 43
• Safety Statements: 24-37
• RIDADR: UN 3334
• WGK Germany: 1
• Hazardous Substances Data: 5788-17-0(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
METHYL 3-METHOXYACRYLATE is used as a chemical intermediate for the synthesis of various pharmaceutical compounds, such as 5-hydroxyquinolines, 7-hydroxyquinolines, and methyl 5-methoxyquinoline-3-carboxylate. These compounds have potential applications in the development of new drugs and therapies.
Used in Chemical Synthesis:
METHYL 3-METHOXYACRYLATE is used as a key intermediate in the chemical synthesis of various organic compounds, contributing to the development of new materials and products in the chemical industry.
Used in Research and Development:
Due to its unique chemical properties, METHYL 3-METHOXYACRYLATE is utilized in research and development for the exploration of new chemical reactions, synthesis methods, and potential applications in various fields, including pharmaceuticals, materials science, and environmental science.

InChI:InChI=1/C5H8O3/c1-7-4-3-5(6)8-2/h3-4H,1-2H3/b4-3+

Upstream product

• 67-56-1 methanol 
• 74783-15-6 C₁₀H₁₉O₈P 
• 292638-85-8 acrylic acid methyl ester 
• 124-41-4 sodium methylate 
• 184377-59-1 E-2-carbomethoxyethenyl p-tolyl sulfoxide 
• 74-88-4 methyl iodide 

Downstream Products

• 107-31-3 Methyl formate 
• 95599-91-0 methyl α-hydroperoxy-α-methoxyacetate 
• 82656-33-5 4,5-Dimethoxy-5-(methoxy-phenyl-methyl)-5H-furan-2-one 
• 127762-40-7 (3S,6S)-3-[1,3]Dioxolan-2-yl-6-methyl-4-trimethylsilanyloxy-cyclohexa-1,4-dienecarboxylic acid methyl ester 
• 150151-36-3 Dihydro-3,6-diheptyl-5-(phenylmethyl)-1,2,4,5-trioxazine 
• 6214-29-5 (2E)-3-methoxy-2-propenoic acid 
• 22609-96-7 4-methoxy-5-phenylfuran-2(5H)-one 
• 69556-71-4 (RS)-4-methoxy-5-methyl-5H-furan-2-one 
• 163041-47-2 (Z)-3-methoxy-2-iodo-acrylic acid methyl ester 
• 191330-98-0 2-Bromo-3,3-dimethoxy-propionic acid methyl ester 
• 115130-74-0 (E)-3-(2,4,6-trimethoxy-phenyl)-acrylic acid methyl ester 

Relevant articles and documents

Nucleophilic attack of 2-sulfinyl acrylates: A mild and general approach to sulfenic acid anions

An increasing number of reactions of sulfenic acid anions are being demonstrated in the literature. As such, mild, general and reliable means for the generation of sulfenates are due. In the current paper, an addition/elimination of 2-sulfinyl acrylates using various nucleophiles is demonstrated and evaluated as a protocol for alkane- and arenesulfenate generation. Cyclohexanethiolate, methoxide and n-butyllithum each exhibit some merit for the reaction, and the thiolate is established as a mild, selective and effective reagent to release sulfenates from 2-sulfinyl acrylates. The stereospecificity of the addition/elimination of each nucleophile is recognized, and an explanation for the specificity is offered for thiolate and methoxide.

Palladium-catalyzed aerobic oxidation of terminal olefins with electron-withdrawing groups in scCO2

Product control of palladium-catalyzed aerobic oxidation of terminal olefins with electron-withdrawing groups can be achieved through modifying reaction conditions. When the oxidant, such as CuCl2/O2, benzoquinone/O2 or O2, was present in scCO2, aerobic oxidation of terminal olefins goes smoothly. With enough MeOH and sufficient oxygen, acetalization preponderated over cyclotrimerization, while with little MeOH as co-solvent in scCO2 or no MeOH in DMF and an appropriate pressure of O2, cyclotrimerization of terminal olefins became the dominated reaction. When oxygen is absent and triethylamine was added into the reaction system, palladium-catalyzed C-N bond formation occurs to produce β-amino acid derivatives as the sole product.

β-Sulfinyl acrylate esters as a convenient source of alkane- and arenesulfenate anions

Methyl acrylate esters bearing alkane- and arenesulfinyl units on the 2-carbon liberate sulfenate anions upon nucleophilic attack. The sulfenates are readily captured through sulfur alkylation. When a sulfenate derived from R-cysteine is generated, diastereoselective benzylation is observed.

Palladium(II)-catalyzed oxidation of acrylate esters to acetals in supercritical carbon dioxide

The development of a new palladium(II)-catalyzed oxidation of methyl acrylate, affording methyl 3,3-dimethoxypropanoate in excellent conversion and selectivity in supercritical CO2, is presented.

STABILITE THERMIQUE ET ALCOOLYSE DE QUELQUES YLURES DE TYPE

The thermal stability and alcoholysis reaction concerning ylides of the type X3P = is reported.These ylides undergo an addition reaction with methanol leading apparently to a pentacoordinated species which decomposes with or without breaking of the P-C bond.