147595-83-3

Upstream product

• 158557-16-5 (2R,3S)-3-<(p-methoxybenzyl)oxy>-2,4-dimethyl-1-phenylthiopentane 
• 189069-42-9 (-)-(R)-4-benzyl-3-((2R,3S)-3-hydroxy-2,4-dimethylpentanoyl)oxazolidin-2-one 
• 98391-91-4 (2S,3S)-2,4-dimethylpentane-1,5-diol 
• 609828-70-8 Methanesulfonic acid (2S,3S)-3-(4-methoxy-benzyloxy)-2,4-dimethyl-pentyl ester 
• 380497-28-9 (2S,3S)-3-[(4-methoxyphenyl)methoxy]-2,4-dimethylpentan-1-ol 
• 380497-27-8 1-[(4S,5S,2R)-5-methyl-4-(methylethyl)(1,3-dioxan-2-yl)]-4-methoxybenzene 

Downstream Products

• 163932-44-3 C₄₆H₇₄O₁₁ 
• 609828-56-0 7-(9-{(1E)(3S,4S)-4-[(4-methoxyphenyl)methoxy]-3,5-dimethylhex-1-enyl}(7S,9R)-6,10-dioxospiro[4.5]dec-7-yl)-1-{9-[(1S)-1-methyl-2-(phenylmethoxy)ethyl](7S,9R)-6,10-dioxaspiro[4.5]dec-7-yl}(4S,6S)-4-hydroxy-6-(tert-butyldimethylsilyloxy)heptan-2-one 
• 609828-47-9 tert-butyl (6E)(3S,8S,9S,5R)-3,5-bis(tert-butyldimethylsilyloxy)-9-[(4-methoxyphenyl)methoxy]-8,10-dimethyl-undec-6-enoate 
• 1026361-09-0 tert-butyl 2-(9-{(1E)(3S,4S)-4-[(4-methoxyphenyl)methoxy]-3,5-dimethylhex-1-enyl}(7S,9R)-6,10-dioxaspiro[4.5]dec-7-yl)acetate 
• 609828-51-5 2-(9-{(1E)(3S,4S)-4-[(4-methoxyphenyl)methoxy]-3,5-dimethylhex-1-enyl}(7S,9R)-6,10-dioxaspiro[4.5]dec-7-yl)ethanal 

Relevant academic research and scientific papers

Synthesis of the antifungal macrolide antibiotic (+)-roxaticin

The total synthesis of the antifungal macrolide antibiotic roxaticin has been accomplished. The synthesis relies principally on aldol and directed reduction steps to construct the extended 1,3-polyol array present in the natural product. Three principal n

Total Synthesis of the Polyene Macrolide Antibiotic Roxaticin. II. Total Synthesis of the Roxaticin

Roxaticin has been synthesized in a convergent manner from the polyol segment 2, which was prepared by the Julia coupling reaction of sulfone 4 and aldehyde 8, and the polyene phosphonate 3.The cyclization was achieved by macrolactonization.

Total synthesis of the polyene macrolide roxaticin

Roxaticin has been synthesized in a convergent manner. The polyol and polyene fragments were coupled by Horner-Emmons reaction and the cyclization was achieved by macrolactonization.