1476-78-4 Usage
Uses
The oxidative 6α-metabolite of 17β-Estradiol (E887995) and Estrone (E889050) formed by 15 selectively expressed human cytochrome p450 isoforms.
Definition
ChEBI: A 6alpha-hydroxy steroid that is estrone substituted by an alpha-hydroxy group at position 6.
Check Digit Verification of cas no
The CAS Registry Mumber 1476-78-4 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,4,7 and 6 respectively; the second part has 2 digits, 7 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 1476-78:
(6*1)+(5*4)+(4*7)+(3*6)+(2*7)+(1*8)=94
94 % 10 = 4
So 1476-78-4 is a valid CAS Registry Number.
InChI:InChI=1/C18H22O3/c1-18-7-6-12-11-3-2-10(19)8-14(11)16(20)9-13(12)15(18)4-5-17(18)21/h2-3,8,12-13,15-16,19-20H,4-7,9H2,1H3/t12-,13-,15+,16?,18+/m1/s1
1476-78-4Relevant articles and documents
IDENTIFICATION OF 6α- AND 7α-HYDROXYESTRONE AS MAJOR METABOLITES OF ESTRONE AND ESTRADIOL IN PORCINE UTERUS
Maschler, I.,Ball, P.,Bayerkoehler, G.,Gaues, J.,Knuppen, R.
, p. 597 - 608 (2007/10/02)
Polar metabolites extracted from the effluents of viable porcine uterine strips superfused with either 6,7-3H-estrone or 6,7-3H-estradiol were identified as a 1 : 1 mixture of 6α-hydroxyestrone and 7α-hydroxyestrone by paper chromatography in various systems, derivatization and crystallizations to a constant specific activity.The hydroxylated compounds are the only derivatives detected after estrone superfusion.The major metabolite of estradiol released in short-time experiments is estrone followed by its 6α- and 7α-hydroxylated derivatives.
