14760-30-6

Usage

Uses

Used in Pharmaceutical Research:
(2E)-2-[1-(3-chlorophenyl)ethylidene]hydrazinecarboxamide is used as a pharmaceutical research compound for its potential applications in drug development. Its unique structure and functional properties make it a promising candidate for the discovery of new therapeutic agents.
Used in Chemical Research:
(2E)-2-[1-(3-chlorophenyl)ethylidene]hydrazinecarboxamide is used as a chemical research compound to study its properties and potential reactions with other compounds. This can lead to the development of new chemical processes and the synthesis of novel compounds with various applications.
Used in Medicinal Chemistry:
(2E)-2-[1-(3-chlorophenyl)ethylidene]hydrazinecarboxamide is used as a medicinal chemistry compound for the design and synthesis of new drugs. Its structural features can be exploited to create molecules with specific biological activities, potentially leading to the development of new treatments for various diseases.
Used in Organic Synthesis:
(2E)-2-[1-(3-chlorophenyl)ethylidene]hydrazinecarboxamide is used as an organic synthesis compound to create new organic molecules with diverse applications. Its unique structure can be utilized in various synthetic routes, enabling the production of novel compounds for research and development purposes.

Upstream product

• 563-41-7 semicarbazide hydrochloride 
• 99-02-5 3'-Chloroacetophenone 

Downstream Products

• 681260-24-2 3-(3-chlorophenyl)-1H-pyrazole-4-carbaldehyde 
• 99-02-5 3'-Chloroacetophenone 

Relevant academic research and scientific papers

New INH-pyrazole analogs: Design, synthesis and evaluation of antitubercular and antibacterial activity

With the aim of developing promising antitubercular and antibacterial leads, we have designed and synthesized a new series of isonicotinohydrazide based pyrazole derivatives (5a-r). All new derivatives (4a-b and 5a-r) were screened for in vitro antimycoba

New approach towards the synthesis of selenosemicarbazones, useful compounds for Chagas' disease

Herein, we describe a new approach towards the synthesis of selenosemicarbazones. The reaction involves an O-Se exchange of semicarbazones using Ishihara reagent. Eleven selenosemicarbazones were prepared using this methodology, with low to moderate yields. Among the prepared compounds the m-bromo phenyl methyl derivative 1b was selected to be evaluated in vivo, in a murine model of acute Chagas' disease. Compound 1b 10 mg/kg bw/day reduced 50% of parasitaemia profile compared with the control group, but was less effective than Benznidazole (50 mg/kg bw/day reduced 90%) and toxic. These studies are important to guide future Chagas drug design.

Synthesis and antitubercular and antibacterial activity of some active fluorine containing quinoline–pyrazole hybrid derivatives

In an attempt to develop newer antitubercular and antibacterial agents against the increasing bacterial resistance, we have designed new quinoline–pyrazole analogs (8a–u) following the molecular hybridization approach. The structure of one of the final compounds, 8a was unambiguously confirmed by single crystal X-ray diffraction (SC-XRD) analysis. The target compounds were evaluated for their antitubercular activity against Mycobacterium tuberculosis and antibacterial activity against three common pathogenic bacterial strains. Four derivatives (8b, 8c, 8j and 8o) displayed significant antitubercular activity. The compounds derived from 8-trifluoromethylquinoline and 6-fluoroquinoline scaffolds with halogen substitution on the pyrazole ring exhibited superior inhibition activity than corresponding 6-methoxyquinoline analogs. The cytotoxic studies revealed that the active compounds are nontoxic to normal Vero cell lines with selectivity index values ≥10, which indicate the suitability of these compounds for further drug development. The in silico molecular docking study demonstrated strong binding affinity of the compounds with the target enzymes (InhA, CYP121 and TMPK) of M. tuberculosis. Further, the in vitro antibacterial activity of compounds 8b, 8c, 8d and 8g is comparable with that of the reference drug, Ciprofloxacin.