147610-86-4

Upstream product

• 1419221-95-6 6-benzyl 1-methyl 6-azaspiro[2.5]octane-1,6-dicarboxylate 
• 147610-85-3 6-(benzyloxycarbonyl)-6-azaspiro[2.5]octane-1-carboxylic acid 
• 75-65-0 tert-butyl alcohol 
• 147610-84-2 6-benzyl 1-ethyl 6-azaspiro[2.5]octane-1,6-dicarboxylate 

Downstream Products

• 1428582-20-0 benzyl 1-amino-6-azaspiro[2.5]octane-6-carboxylate hydrochloride 

Relevant academic research and scientific papers

ION CHANNEL INHIBITORY COMPOUNDS, PHARMACEUTICAL FORMULATIONS AND USES

The present invention is directed towards new chemical entities which primarily inhibit the human T-type calcium channels and differentially modulate other key ion channels to control cell excitability, and abnormal neuronal activity particularly involved in the development and maintenance of persistent or chronic pain, and / or neurological disorders. These novel compounds are useful in the treatment and prevention of neurological and psychiatric disorders and diseases in which these ion channels are involved. The invention is also directed towards pharmaceutical formulations comprising these compounds and the uses of these compounds.

N-PIPERIDIN-4-YL DERIVATIVES

The invention relates to a N-piperidin-4-yl derivative having the general Formula I or a pharmaceutically acceptable salt thereof, to pharmaceutical compositions comprising the same and to the use of said N-piperidin-4-yl derivatives for the treatment and prevention of endometriosis, for the treatment and prevention of pre-menopausal and peri-menopausal hormone-dependent breast cancer, for contraception, or for the treatment of uterine fibroids or other menstrual-related disorders.