1476776-88-1

Basic information

• Product Name: C₂₄H₂₇N₃O₄
• CAS NO: 1476776-88-1
• Molecular Weight: 421.496
• Mol File: 1476776-88-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₄H₂₇N₃O₄(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₄H₂₇N₃O₄(1476776-88-1)
• EPA Substance Registry System: C₂₄H₂₇N₃O₄(1476776-88-1)

Safety Data

• Hazardous Substances Data: 1476776-88-1(Hazardous Substances Data)

Upstream product

• 6340-79-0 4-oxo-4-(4-bromophenyl)butanoic acid 
• 1284448-67-4 isopropyl 4-(4-bromophenyl)-4-oxobutanoate 
• 1476776-39-2 isopropyl 3-(2-(4-bromophenyl)oxiran-2-yl)-propanoate 
• 1476776-40-5 isopropyl 4-(4-bromophenyl)-5-oxopentanoate 
• 1476776-44-9 (S)-5-(4-bromophenyl)piperidin-2-one 
• 1476776-53-0 (S)-3-(4-bromophenyl)piperidin-1-ium 4-methylbenzenesulfonate 
• 1335523-82-4 4-(3S-piperidine-3-yl)bromobenzene 
• 1476776-62-1 C₁₁H₁₆BrNO 
• 1476776-64-3 (S)-tert-butyl (2-(4-bromophenyl)-5-hydroxypentyl)carbamate 
• 1476776-66-5 (S)-4-(4-bromophenyl)-5-((tert-butoxycarbonyl)amino)pentyl methanesulfonate 
• 108-86-1 bromobenzene 
• 1476776-61-0 C₁₁H₁₃BrO₂ 

Relevant articles and documents

Process development of C-N cross-coupling and enantioselective biocatalytic reactions for the asymmetric synthesis of niraparib

Process development of the synthesis of the orally active poly(ADP-ribose)polymerase inhibitor niraparib is described. Two new asymmetric routes are reported, which converge on a high-yielding, regioselective, copper-catalyzed Narylation of an indazole derivative as the late-stage fragment coupling step. Novel transaminase-mediated dynamic kinetic resolutions of racemic aldehyde surrogates provided enantioselective syntheses of the 3-aryl-piperidine coupling partner. Conversion of the C-N cross-coupling product to the final API was achieved by deprotection and salt metathesis to isolate the desired crystalline salt form.