147687-45-4Relevant academic research and scientific papers
Factors influencing the cytotoxicity of α-methylene-γ-hydroxy esters against pancreatic cancer
Ramachandran, P. Veeraraghavan,Helppi, Matthew A.,Lehmkuhler, Arlie L.,Marchi, Jennifer M.,Schmidt, C. Max,Yip-Schneider, Michele T.
, p. 4270 - 4273 (2015/11/03)
A systematic study to identify the factors influencing the cytotoxicity of α-methylene-γ-hydroxy esters against three pancreatic cancer cell lines (Panc-1, MIA-PaCa-2, and BxPC-3) has established that, in addition to Michael acceptor abilities, the possibility to lactonize to α-methylene-γ-butyrolactones is as important. The substitution pattern and the number of carbons between the hydroxy and ester moieties also influence the bio-activity.
Cascade synthesis of spirooxindole δ-lactone derivatives through N-aryl hydroxymethylacrylamides with xanthates
Wang, Shucheng,Huang, Xuhu,Wen, Yanzhao,Ge, Zemei,Wang, Xin,Li, Runtao
supporting information, p. 8117 - 8122 (2015/12/30)
A novel and highly efficient cascade synthesis of spirooxindole δ-lactone derivatives from N-aryl hydroxymethylacrylamides and xanthates in good yields is described. The reaction proceeds through a radical addition/cyclization and ester exchange, in which two new C-C bonds and one C-O bond were formed.
Solid-phase synthesis of 3-hydroxy-2-methylenealkanoates and their derivatives using polymer-supported 2-(phenylseleno)propanoate
Sheng, Shou-Ri,Huang, Fang-Fang,Lin, Shu-Ying,Liu, Xiao-Ling,Huang, Xian
, p. 1373 - 1377 (2008/02/12)
A novel facile procedure for the solid-phase organic synthesis of 3-hydroxy-2-methylenealkanoates and their derivatives in good yields and with excellent purities using polymer-supported 2-(phenylseleno)propanoate is described. Georg Thieme Verlag Stuttgart.
A novel liquid-phase synthesis of Baylis-Hillman products using PEG-supported α-phenylselenopropionate ester
Sheng, Shou-Ri,Wang, Qiong,Wang, Qiu-Ying,Guo, Lei,Liu, Xiao-Ling,Huang, Xian
, p. 1887 - 1890 (2008/02/08)
Treatment of the lithio derivative of novel PEG-supported α-phenylselenopropionate ester with aldehydes and subsequent cleavage from the PEG support by oxidative elimination with 30% hydrogen peroxide efficiently afforded Baylis-Hillman products in good y
Experimental and Theoretical Study on the Olefin Metathesis of Alkenyl Baylis-Hillman Adducts Using Second-Generation Grubbs Catalyst
Lee, Mi Jung,Lee, Ka Young,Lee, Jin Yong,Kim, Jae Nyoung
, p. 3313 - 3316 (2007/10/03)
We have investigated the olefin metathesis from alkenyl Baylis-Hillman adducts using second-generation Grubbs catalyst. In the experiment, the ring-closing metathesis (RCM) product could be found, while the cross-metathesis (CM) products were f
Unusual, strained heterocycles: 3-Alkylidene-2-methyleneoxetanes from Morita-Baylis-Hillman-type adducts
Martinez, Isamir,Andrews, Alexander E.,Emch, Joseph D.,Ndakala, Albert J.,Wang, Jun,Howell, Amy R.
, p. 399 - 402 (2007/10/03)
(Matrix presented) 3-Alkylidene-2-methyleneoxetanes have been prepared by treating α-alkylidene-β-lactones, derived from Morita-Baylis-Hillman-type adducts, with dimethyltitanocene. Preliminary studies of the reactivity of these little known, strained het
A novel precipitating auxiliary approach to the purification of Baylis-Hillman adducts
Bosanac,Wilcox
, p. 1618 - 1619 (2007/10/03)
Diaryl alkene alcohol 1 is a 'precipiton', a precipitating auxiliary that is used to aid the isolation of Baylis-Hillman adducts.
Synthesis, resolution and assignment of absolute configuration of 2-(α-hydroxy)aryl acrylate esters
Drewes,Emslie,Field,Khan,Ramesar
, p. 255 - 260 (2007/10/02)
(-)(R,R)-2-Amino-1-(4-nitrophenyl)propan-1,3-diol 3 has been used to resolve racemic 3-hydroxy-2-methylene-3-phenylpropanoic acid 1a. Conversion of the laevorotatory enantiomer into anti and syn methyl 3-hydroxy-2-methyl-3-phenypropanoate, 2a and 2b respe
