147698-79-1Relevant articles and documents
The synthesis and crystal and molecular structures of 3,7-diacetyl- and 3,7-bis(thioacetyl)-1,5-dimethyl-3,7-diazabicyclo[3.3.1]nonanes
Palyulin,Emets,Potekhin,Lysov,Chertkov,Zefirov
, p. 289 - 292 (2000)
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SYNTHESIS AND CONVERSIONS OF POLYHEDRAL COMPOUNDS 17. CONVERSION OF 1,3-DIAZA- AND 1,3,5-TRIAZAADAMANTANES TO NITROGEN-CONTAINING PENTACYCLIC COMPOUNDS
Minasyan, G. G.,Agadzhanyan, Ts. E.,Adamyan, G. G.
, p. 94 - 98 (1994)
It has been shown that derivatives of 1,3-diaza- and 1,3,5-triazaadamantanes, and also derivatives of 3,7-diazabicyclononane, interact with 3,7-bis(bromoacetyl)-3,7-diaza- and 3,7-bis(bromoacetyl)-1,3,7-triazabicyclononanes in the presence of bases to form previously unknown types of heteropolyhedral structures - nitrogen-containing pentacyclic compounds.
Novel bispidine-monoterpene conjugates—Synthesis and application as ligands for the catalytic ethylation of chalcones
Dalinger, Alexander I.,Kalinin, Mikhail A.,Kuranov, Sergey O.,Munkuev, Aldar A.,Okhina, Alina A.,Ottenbacher, Roman V.,Patrusheva, Oxana S.,Ponomarev, Konstantin Y.,Rogachev, Artem D.,Salakhutdinov, Nariman F.,Suslov, Evgeniy V.,Vatsadze, Sergey Z.,Volcho, Konstantin P.
, (2021/12/20)
A number of new chiral bispidines containing monoterpenoid fragments have been ob-tained. The bispidines were studied as ligands for Ni-catalyzed addition of diethylzinc to chalcones. The conditions for chromatographic analysis by HPLC-UV were developed,
Synthesis and analgesic activity of amines combining diazaadamantane and monoterpene fragments
Ponomarev, Konstantin,Morozova, Ekaterina,Pavlova, Alla,Suslov, Evgeniy,Korchagina, Dina,Nefedov, Andrej,Tolstikova, Tat'yana,Volcho, Konstantin,Salakhutdinov, Nariman
, p. 773 - 779 (2018/01/16)
Background: It was found earlier that compounds combining diazaadamantane and monoterpene moieties possessed promising analgesic activity along with low acute toxicity and the lack of ulcerogenic activity. Objective: In this paper, new structural analogues of the most active compounds were synthesized and evaluated for their analgesic activity. Methods: Their structures were confirmed by various analytical methods, such as 1H and13C NMR, HRMS. All of them were evaluated for analgesic activity at a dose of 20 mg/kg or less using acetic acid-induced writhing test and hot plate test. Results: Some compounds showed analgesic activity in acetic acid-induced writhing test. One of the synthesized compounds demonstrated high analgesic activity in both tests with 46% effect in acetic acid-induced writhing test and 89% effect in hot plate test. Both structural fragments of this compound did not possess any analgesic effect at a dose of 20 mg/kg. Conclusion: Structure-activity relationships indicated that the most active compound combines fragments of (–)-myrtenal and 6-amino-5,7-dimethyl-1,3-diazaadamantane. Both parts of the molecule are important for demonstrating analgesic activity.
