14770-90-2Relevant articles and documents
Acid-promoted furan annulation and aromatization: An access to benzo[b]furan derivatives
Ao, Jun,Liu, Yidong,Jia, Shiqi,Xue, Lu,Li, Dongmei,Tan, Yu,Qin, Wenling,Yan, Hailong
, p. 433 - 440 (2018/01/03)
An unprecedented PTSA-promoted furan annulation and aromatization in one pot has been developed. This process offers a simple and efficient synthetic route for the construction of various highly substituted benzo[b]furan derivatives, which are widely used not only in drug active molecules but also organic semiconductor and organic light-emitting devices. The preliminary mechanism study indicated this transformation proceeded sequentially via furan annulation and aromatization.
Benzofuran synthesis via copper-mediated oxidative annulation of phenols and unactivated internal alkynes
Zhu, Ruyi,Wei, Jiangbo,Shi, Zhangjie
, p. 3706 - 3711 (2013/11/19)
The first example of copper-mediated oxidative annulation of phenols and unactivated internal alkynes to afford benzofuran derivatives was reported. Various phenols and unactivated internal alkynes were successfully employed. Mechanistic studies disclosed a new strategy on annulations of alkynes with phenols through reversible electrophilic carbocupration of phenol followed by alkyne insertion and cyclization.
