14772-98-6Relevant academic research and scientific papers
Chenodeoxycholic acid and preparation method thereof
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Paragraph 0062; 0064-0069, (2019/06/07)
The invention relates to the field of medicine synthesis, and in particular to chenodeoxycholic acid and a preparation method thereof. The preparation method of the chenodeoxycholic acid provided by the invention comprises the following steps of: using 3 alpha,7 alpha-dihydroxy-5 alpha-ursodeoxycholic acid as raw materials to form an intermediate compound E through chemical reaction; then, performing chemical reaction on the intermediate compound E to form the chenodeoxycholic acid. The structure formula of the intermediate compound E is shown in the description, wherein R1 is alkyl, alkenylor aromatic group; R2 is acyl. The preparation method has the advantages that extracted byproducts can be used as raw materials for fast synthesizing the chenodeoxycholic acid; each step in the process is mild in condition; the yield is high; the method is suitable for mass preparation.
CO2 incubator ozone sterilization device
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, (2007/10/16)
PROBLEM TO BE SOLVED: To provide an apparatus that ensures sterilization of a COincubator, has no leakage of fed ozone gas to the outside, uniformly circulates ozone in a storage and constantly and continuously controls an ozone concentration.SOLUTION: The apparatus for ozone sterilization of a COincubator includes: a sterilization tent 1 with an airtight hole 8a for airtightly protruding a leading end part of a tube connection part 14a provided in the COincubator 11 to the outside and a discharge part 9a for discharging ozone gas to the outside, for covering the COincubator 11 airtightly; an ozone gas generator 18 for applying circulating sterilization to the inside and the outside of the COincubator 11 covered by the sterilization tent 1 by pressure-feeding the ozone gas to the tube connection part 14a; and an ozone gas neutralization unit 26 for neutralizing and eliminating the ozone gas discharged from the discharge part 9a.
Potential bile acid metabolites. XXI. A new synthesis of allochenodeoxycholic and allocholic acids
Iida,Nishida,Chang,Niwa,Goto,Nambara
, p. 763 - 765 (2007/10/02)
A new method for the preparation of allochenodeoxycholic and allocholic acids is described. The key steps in the synthesis are 1) simultaneous oxidation-dehydrogenation reaction of 3α-hydroxy 5β-bile acid formyl esters with iodoxybenzene catalyzed by benzeneseleninic anhydride, 2) reductive allomerization at C-5 of the 1,4-dien-3-oxo bydroxy acids with lithium/liq. ammonia, and 3) subsequent reduction of the resulting 3-oxo 5α-compounds with K-Selectride.
POTENTIAL BILE ACID METABOLITES. X. SYNTHESES OF STEREOISOMERIC 3,7-DIHYDROXY-5α-CHOLANIC ACIDS
Iida, Takashi,Momose, Toshiaki,Nambara, Toshio,Chang, Frederic C.
, p. 1929 - 1933 (2007/10/02)
New synthetic routes to allochenodeoxycholic (3α,7α-dihydroxy-5α-cholanic) and alloursodeoxycholic (3α,7β-dihydroxy-5α-cholanic) acids, and their stereoisomers are described.Treatments of allo 7α-hydroxy-3β-tosyloxy ester with N,N-dimethylformamide and of allo 7α-mesyloxy-3β-tosyloxy and 3β-cathyloxy-7α-mesyloxy esters with potassium superoxide-crown ether afforded the desired 3α,7α-, 3α,7β-, and 3β,7β-dihydroxy stereoisomers, respectively, in high yield.Highperformance liquid chromatography was of key importance in characterizing the compounds and determining their purity.Keywords--bile acid; allo bile acid; 3,7-dihydroxy-5α-cholanic acid; allochenodeoxycholic acid; alloursodeoxycholic acid; N,N-dimethylformamide reaction; potassium superoxide-18-crown-6 ether reaction; HPLC
BILE ACIDS LXIX. SELECTIVE K-SELECTRIDE REDUCTION OF 3,7-DIKETO STEROIDS
Tal, Daniel M.,Frisch, G. Douglas,Elliott, William H.
, p. 851 - 854 (2007/10/02)
The K-Selectride reduction at low temperature (-45 C) of 7-oxo-5α-cholestan-3β-yl acetate and methyl 7-oxo-3α-hydroxy-5β-cholanoate resulted in almost quantitative yield of the 7α-alcohol in the 5α-compound but only moderate yield of the 5β-analog.The simultaneous reduction of two carbonyl in the 3 and 7 positions afforded good to excellent yields of the diaxial diol in planar steroids (methyl 3,7-dioxo-5α-cholanoate, 3,7-dioxo-5α-cholestane and methyl 3,7-dioxo-5α-cholestan-27-oate) and only 14percent of 3α,7α-(OH)2 from methyl 3,7-dioxo-5β-cholanoate.
