15357-34-3

Usage

Uses

Used in Pharmaceutical Industry:
4-[(10R,13R,17R)-3,7-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoic acid is used as a potential therapeutic agent for various conditions due to its structural resemblance to endogenous hormones. Its application may include the treatment of hormonal imbalances or diseases that can be modulated by corticosteroids or sex hormones, leveraging its interaction with cellular receptors to elicit desired physiological responses.
Used in Research and Development:
In the scientific community, 4-[(10R,13R,17R)-3,7-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoic acid serves as a valuable tool for studying the mechanisms of hormone action, receptor binding, and the development of new drugs. It can be utilized in assays and experiments to understand the effects of steroidal compounds on cellular processes and to screen for potential therapeutic agents with improved efficacy and reduced side effects.

InChI:InChI=1/C24H40O4/c1-14(4-7-21(27)28)17-5-6-18-22-19(9-11-24(17,18)3)23(2)10-8-16(25)12-15(23)13-20(22)26/h14-20,22,25-26H,4-13H2,1-3H3,(H,27,28)/t14-,15-,16-,17-,18?,19+,20-,22+,23+,24-/m1/s1

Upstream product

• 14773-00-3 methyl (5β,7α)-12-hydroxy-3-oxo-cholan-24-oate 

Downstream Products

• 88165-77-9 bis(3α-phenylsulfonyloxy-5β-cholansaeure-7α-yl)diester 
• 92054-20-1 5β-cholanic acid-3α,7α-diol di-p-fluorobenzoate 
• 25613-05-2 tauro 3α,6β,7α-trihydroxy-5β-cholanoate 
• 25613-05-2 tauro 3α,6α,7α-trihydroxy-5β-cholanoate 
• 14772-98-6 3α,7α-dihydroxy-5α-cholanoic acid methyl ester 
• 474-25-9 chenodeoxycholic acid 

Relevant academic research and scientific papers

CO2 incubator ozone sterilization device

PROBLEM TO BE SOLVED: To provide an apparatus that ensures sterilization of a COincubator, has no leakage of fed ozone gas to the outside, uniformly circulates ozone in a storage and constantly and continuously controls an ozone concentration.SOLUTION: The apparatus for ozone sterilization of a COincubator includes: a sterilization tent 1 with an airtight hole 8a for airtightly protruding a leading end part of a tube connection part 14a provided in the COincubator 11 to the outside and a discharge part 9a for discharging ozone gas to the outside, for covering the COincubator 11 airtightly; an ozone gas generator 18 for applying circulating sterilization to the inside and the outside of the COincubator 11 covered by the sterilization tent 1 by pressure-feeding the ozone gas to the tube connection part 14a; and an ozone gas neutralization unit 26 for neutralizing and eliminating the ozone gas discharged from the discharge part 9a.

A stereoselective synthesis of the allo-bile acids from the 5β-isomers

The allo-bile acids are a subset of the family of steroidal detergents found in most vertebrates. Because there are no major biological feedstocks for isolation of the allo-bile acids, they must be synthesized from the abundant 5β-reduced isomers. Here we report a general set of methods for the synthesis of allo-bile acids from the corresponding 5-β isomers demarcated by a selective C-3 oxidation, IBX unsaturation, and stereoselective saturation.

Introducing Δ11 unsaturation into steroid compounds

A process for the introduction of Δ11 unsaturation into steroid compounds having a C-12 sulfonate ester group is described. Dehydrosulfonation is carried out by reacting the sulfonate with a hexaalkylphosphoric triamide. The process is particularly useful with steroid compounds that also contain a blocked C-7 hydroxy group. The process yields the 11-enate in preference to the 6,11-dienate. The yield of the process can be increased by carrying out the reaction in the presence of a weak base.