14773-85-4

Upstream product

• 1189-71-5 isocyanate de chlorosulfonyle 
• 108-95-2 phenol 

Downstream Products

• 80240-11-5 iodo-2 ethylcarbamate de N-phenoxysulfonyle 
• 77297-97-3 3-tert-Butyl-3-isopropyl-1-(phenoxysulfonyl)-4-thioxo-2-azetidinon 
• 112222-22-7 2,6-Di-tert-butylcyclohexanthiocarbonsaeure-O-phenylester 
• 112222-21-6 5-(2,6-Di-tert-butylcyclohexyl)-N-(phenoxysulfonyl)-3H-1,2,4-dithiazol-3-imin 
• 112221-96-2 3-tert-Butyl-3-methyl-4-(phenoxysulfonylimino)-2-thietanon 
• 112222-24-9 2,4,6-Tri-tert-butylcyclohexanthiocarbonsaeure-O-phenylester 
• 112222-23-8 N-(Phenoxysulfonyl)-5-(2,4,6-tri-tert-butylcyclohexyl)-3H-1,2,4-dithiazol-3-imin 
• 112222-15-8 3-tert-Butyl-3-cyclohexyl-1-(phenoxysulfonyl)-4-thioxo-2-azetidinon 
• 80240-13-7 phenoxysulfonyl-3 oxazolidinone-2 
• 233756-84-8 4-hydroxymethyl-3-phenoxysulfonyl-1,3-oxazolidin-2-one 

Relevant academic research and scientific papers

NOVEL SULFONAMIDE DERIVATIVE

A compound of the formula (1): wherein m, n and p is independently an integer of 0 to 4 with the proviso that 3 a?| m + n a?| 8; X is the formula: NR4, etc.; R1, R3 and R4 are a substituted or unsubstituted aryl group, etc.; R2 is a hydrogen atom, etc.; a, b, c, d, e and f are a hydrogen atom or a substituted or unsubstituted alkyl group, etc.; Y is the formula: -SO2-, etc.; and Z is an oxygen atom, etc.; or a prodrug thereof or a pharmaceutically acceptable salt of the same has an activity of potentiating an expression of a low density lipoprotein receptor and thus is useful as an agent for treating hyperlipidemia or arteriosclerosis.

Preparation and antimicrobial studies of acyclic sulfamates.

A series of acyclic sulfamates have been prepared and tested for antimicrobial activity. Thus, the oxysulfonyl isocyanates, ROSO2NCO (1a, R = 4-methoxyphenyl; 1b, R = phenyl; 1c, R = 4-chlorophenyl and 1d, R = 2,2,2-trifluoroethyl) have been prepared in 76-91% yield from chlorosulfonyl isocyanate. Treatment of 1a-d with glycidol gave the glycidyl carbamates 2a d. Internal cyclisation afforded the corresponding 4-hydroxymethyl-2-oxazolidinones 3a-d, which in turn were hydrolysed to give the free amino alcohols 4a-d. The yields were in the range 39-85%. A preliminary agar diffusion test of 2a-d, 3a-d, 4a-d indicated 2a-d and 3c to be possible antimicrobial agents. A more thorough analysis of these compounds revealed a minimum inhibition concentration (MIC) of 128 and 64 mg l-1 for glycidyl p-methoxyphenoxysulfonylcarbamate (2a) and glycidyl phenoxysulfonylcarbamate (2b) respectively, against Branhamella catarrhalis.

SYNTHESES A L'AIDE D'HETEROCUMULENES. 3. NOUVELLES OXAZOLIDINONES-2 ET IMIDAZOLIDINONES-2 A PARTIR DE L'ISOCYANATE DE PHENOXYSULFONYLE.

We report here, the first use in heterocyclic synthesis of the phenoxysulfonyl isocyanate that reacts with ω-halogeno-alcohols and β-halogeno-ethylamines to give a new family of 2-oxazolidinones and 2-imidazolidinones.