147749-72-2Relevant academic research and scientific papers
Diastereoselective synthesis and optical resolution of 3,4-substituted tetrahydroisoquinolin-4-ols
Kihara, Masaru,Ikeuchi, Motoki,Jinno, Kaori,Kashimoto, Minoru,Kobayashi, Yoshimaro,Nagao, Yoshimitsu
, p. 1017 - 1024 (2007/10/02)
Trans-3,4-substituted 1,2,3,4-tetrahydroisoquinolin-4-ols were prepared diastereoselectively by an insertion reaction with zerovalent nickel and by Barbier reaction with butyllithium of N-(2-iodobenzyl)phenacylamines. The isoquinolin-4-ols were resolved by means of HPLC method and the absolute configurations were determined.
