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Usage

Uses

Used in Pharmaceutical Industry:
(2-iodophenyl)-N-methylmethanamine is utilized as a ligand in the development of radiolabeled imaging agents for positron emission tomography (PET) scans. Its iodine atom and unique structure make it a promising candidate for enhancing the imaging capabilities of PET scans, which are crucial for diagnosing various diseases, including cancer.
Additionally, (2-iodophenyl)-N-methylmethanamine is explored as a precursor in the synthesis of other pharmaceutical compounds. Its chemical properties and potential applications contribute to the advancement of drug development, as it can be used to create new medications with improved efficacy and safety profiles.

Upstream product

• 58084-22-3 2-iodo-N-methyl-benzamide 
• 26260-02-6 2-iodobenzaldehyde 
• 593-51-1 methylamine hydrochloride 
• 1587717-82-5 (R)-N-(2-iodobenzyl)-2-methylpropane-2-sulfinamide 
• 1587718-03-3 (R)-N-(2-iodobenzyl)-N-methyl-t-butanesulfinamide 
• 88-67-5 2-Iodobenzoic acid 
• 5159-41-1 2-iodobenzyl alcohol 
• 74-89-5 methylamine 
• 40400-13-3 2-Iodobenzyl bromide 
• 698-19-1 N-methyl-2-bromobenzylamine 
• 59473-45-9 2-(chloromethyl)iodobenzene 

Downstream Products

• 854392-96-4 (2-iodo-benzyl)-methyl-(2-nitro-benzyl)-amine 
• 857785-85-4 (2-bromo-benzyl)-(2-iodo-benzyl)-methyl-amine 
• 140420-15-1 1-(4-Ethyl-phenyl)-2-[(2-iodo-benzyl)-methyl-amino]-ethanone 
• 131326-78-8 1-(3-Chloro-phenyl)-2-[(2-iodo-benzyl)-methyl-amino]-ethanone 
• 140420-20-8 1-Cyclohexyl-2-[(2-iodo-benzyl)-methyl-amino]-ethanone 
• 147749-70-0 α-ethyl-N-(2-iodobenzyl)-N-methylphenacylamine 
• 131326-80-2 1-(4-Fluoro-phenyl)-2-[(2-iodo-benzyl)-methyl-amino]-ethanone 
• 140420-19-5 1-[(2-Iodo-benzyl)-methyl-amino]-propan-2-one 
• 147749-72-2 N-(2-iodobenzyl)-N-methyl-α-phenylphenacylamine 
• 34137-41-2 trans-2,3-Dimethyl-4-benzyliden-1,2,3,4-tetrahydroisochinolin 
• 1092451-58-5 C₁₇H₁₉IN₂S 
• 1263788-12-0 C₁₂H₁₂IN₃O 
• 1263787-79-6 C₁₇H₁₅IN₂O 
• 1263787-87-6 C₁₈H₁₇IN₂O 

Relevant academic research and scientific papers

Sulfur-Based Chiral Iodoarenes: An Underexplored Class of Chiral Hypervalent Iodine Reagents

Chiral hypervalent iodine reagents are active players in modern stereoselective organic synthesis. Structurally diverse chiral hypervalent iodine reagents have been synthesised and extensively studied, but hypervalent iodine reagents containing chiral sul

Palladium-Catalyzed Domino Heck/C-H Activation/Decarboxylation: A Rapid Entry to Fused Isoquinolinediones and Isoquinolinones

A new palladium-catalyzed tandem cyclization of various alkene-tethered aryl iodides has been presented. In this protocol, o-bromobenzoic acids are employed as coupling parters to achieve the insertion of aromatic rings by the cleavage of C(sp2)-Br and decarboxylation, thus assembling various dibenzoisoquinolinediones and dibenzoisoquinolinones. In addition, a seven-membered ring can be constructed by the use of 8-bromo-1-naphthoic acid. Notably, this approach enables regioselective product formation and features broad substrate scope.

Palladium-Catalyzed, Norbornene-Mediated, ortho-Amination ipso-Amidation: Sequential C-N Bond Formation

A palladium-catalyzed, norbornene-mediated ortho- and ipso-C-N bond-forming Catellani reaction is reported. This reaction proceeds through a sequential intermolecular amination followed by intramolecular cyclization of a tethered amide. The products, ortho-aminated dihydroquinolinones, were generated in moderate to good yields and are present in bioactive molecules. This work highlights the challenge of competing intra- vs intermolecular palladium-catalyzed processes.

Synthesis of biaryls via intramolecular free radical ipso-substitution reactions

A variety of functionalised biaryls and heterobiaryls are prepared by intramolecular free radical [1,5]-ipso-substitution using sulfonamide and sulfonate derived tethering chains. The overall efficiency of the process is determined by appropriately positioned substituents on the aromatic acceptor ring. The extension of the process to benzylic sulfonates and their corresponding N-methylsulfonamide alternatives as substrates in potential [1,6]-ipso-substitution reactions leads mainly to the alternative [1,7] addition products.

Oxidant-Free Au(I)-Catalyzed Halide Exchange and Csp2-O Bond Forming Reactions

Au has been demonstrated to mediate a number of organic transformations through the utilization of its π Lewis acid character, Au(I)/Au(III) redox properties or a combination of both. As a result of the high oxidation potential of the Au(I)/Au(III) couple, redox catalysis involving Au typically requires the use of a strong external oxidant. This study demonstrates unusual external oxidant-free Au(I)-catalyzed halide exchange (including fluorination) and Csp2-O bond formation reactions utilizing a model aryl halide macrocyclic substrate. Additionally, the halide exchange and Csp2-O coupling reactivity could also be extrapolated to substrates bearing a single chelating group, providing further insight into the reaction mechanism. This work provides the first examples of external oxidant-free Au(I)-catalyzed carbon-heteroatom cross-coupling reactions.

Benzo[b]furane and benzo[b]thiophene derivatives

The present invention relates to benzo[b]furane and benzo[b]thiophene derivatives of the general formula IV as the free base or salts thereof and their use.