147751-31-3Relevant academic research and scientific papers
Biological evaluation of 1-alkyl-3-phenylthioureas as orally active HDL-elevating agents
Coppola, Gary M.,Damon, Robert E.,Eskesen, J. Bruce,France, Dennis S.,Paterniti Jr., James R.
, p. 113 - 117 (2007/10/03)
A series of 1-alkyl-3-phenylthiourea analogues were prepared and evaluated as HDL- and Apo A-I-elevating and triglyceride-lowering agents. Several derivatives were superior to gemfibrozil (1). The optimal analogue 8d (HDL376) was shown to raise HDL choles
N-phenylthiourea derivatives and pharmaceutical use thereof
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, (2008/06/13)
The invention concerns the use of the compounds of formula I wherein the substituents have various significances, in free form or salt form as appropriate, in the treatment of atherosclerosis. It also concerns pharmaceutical compositions comprising a compound selected from a subgroup thereof. It further concerns a subgroup of compounds thereof, which are novel, per se. The compounds of formula I can be prepared in conventional manner, e.g. by reaction of an isothiocyanate with an amine or conversion of an urea to a thiourea.
