147753-18-2Relevant academic research and scientific papers
A highly enantioselective one-pot synthesis of homoallylic alcohols via tandem asymmetric allyl transfer/olefin cross metathesis
Lee, Cheng-Hsia Angeline,Loh, Teck-Peng
, p. 809 - 812 (2006)
A highly enantioselective one-pot synthesis of linear homoallylic alcohols with terminal ester functionality has been achieved. The reactions were controlled by ordered addition of reagents and catalysts, ensuring complete consumption of aldehyde. The synthetic utility of this strategy has been demonstrated in a short synthesis of a low boiling point intermediate for grahamimycin A.
Diastereoselective synthesis of trifluoromethylated 1,3-dioxanes by intramolecular oxa-Michael reaction
Becerra-Figueroa, Liliana,Brun, Elodie,Mathieson, Michael,Farrugia, Louis J.,Wilson, Claire,Prunet, Jo?lle,Gamba-Sánchez, Diego
, p. 301 - 305 (2017/01/13)
A highly diastereoselective synthesis of trifluoromethylated 1,3-dioxanes is described. The reaction proceeds by an addition/oxa-Michael sequence and works efficiently under mild reaction conditions, with a good substrate scope and acceptable to good yiel
The vinylogous aldol reaction of unsaturated esters and enolizable aldehydes using the novel Lewis acid aluminum tris(2,6-di-2-naphthylphenoxide)
Gazaille, Jeffrey A.,Sammakia, Tarek
supporting information; experimental part, p. 2678 - 2681 (2012/07/28)
The synthesis of the novel Lewis acid, aluminum tris(2,6-di-2- naphthylphenoxide) (ATNP), and its use in the vinylogous aldol reaction between methyl crotonate and enolizable aldehydes are described. ATNP is related to Yamamoto's Lewis acid, aluminum tris(2,6-diphenylphenoxide) (ATPH), but the 2-naphthyl groups more effectively block the α-position of aldehydes, enabling the selective enolization of crotonate esters in the presence of enolizable aldehydes. Vinylogous aldol reactions then proceed smoothly and in high yields with a variety of substrates.
Diastereoselective Synthesis of Protected Syn 1,3-Diols by Base-Catalyzed Intramolecular Conjugate Addition of Hemiacetal-Derived Alkoxide Nucleophiles
Evans, David A.,Gauchet-Prunet, Joelle A.
, p. 2446 - 2453 (2007/10/02)
Reaction of the illustrated unsaturated hydroxy esters (X = OMe, R2 = H, Me) and amides (X = N(Me)OMe, R2 = H, Me) with benzaldehyde and potassium alkoxide or amide bases is reported.The resulting benzylidene acetals are obtained in
