147770-03-4

Basic information

• Product Name: 3-Methyl-1-(2-piperidin-1-yl-phenyl)-butan-1-one
• CAS NO: 147770-03-4
• Molecular Weight: 245.365
• Mol File: 147770-03-4.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 3-Methyl-1-(2-piperidin-1-yl-phenyl)-butan-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Methyl-1-(2-piperidin-1-yl-phenyl)-butan-1-one(147770-03-4)
• EPA Substance Registry System: 3-Methyl-1-(2-piperidin-1-yl-phenyl)-butan-1-one(147770-03-4)

Safety Data

• Hazardous Substances Data: 147770-03-4(Hazardous Substances Data)

Upstream product

• 765306-66-9 3-methyl-1-(2-fluorophenyl)butan-1-ol 
• 765306-65-8 3-methyl-1-[2-(1-piperidinyl)phenyl]butoxime 
• 582-62-7 3-methyl-1-phenylbutan-1-one 
• 1263313-63-8 4-chloro-N-[2-(3-methyl-butyryl)-phenyl]-benzene-sulfonamide 
• 110-89-4 piperidine 
• 626219-78-1 3-methyl-1-(2-fluorophenyl)butan-1-one 
• 873-32-5 2-Chlorobenzonitrile 
• 72752-52-4 2-(piperidin-1-yl)benzonitrile 
• 147769-96-8 3-methyl-1-[2-(piperidin-1-yl)phenyl]butan-1-imine 

Downstream Products

• 108157-52-4 (S)-1-(2-piperidino-phenyl)-3-methyl-1-butylamine 
• 799255-58-6 C₂₃H₃₂N₂ 
• 765306-65-8 3-methyl-1-[2-(1-piperidinyl)phenyl]butoxime 
• 147770-08-9 (R)-(-)-ethyl 2-ethoxy-4-<2-<<3-methyl-1-<2-(1-piperidinyl)phenyl>butyl>amino>-2-oxoethyl>-benzoate 
• 147770-06-7 (S)-(+)-ethyl 2-ethoxy-4-<2-<<3-methyl-1-<2-(1-piperidinyl)phenyl>butyl>amino>-2-oxoethyl>-benzoate 
• 135062-02-1 (S)-repaglinide 
• 219921-97-8 N-<(R)-3-methyl-1-<2-(1-piperidinyl)phenyl>butyl>-N-<(R')-1-phenethyl>-amine 
• 147770-01-2 N-<(S)-3-methyl-1-<2-(1-pieridinyl)phenyl>butyl>-N-<(S')-1-phenethyl>-amine 
• 147769-98-0 N-acetyl-N-<(S)-3-methyl-1-(2-(1-piperidinyl)phenyl)-1-butyl>-amine 
• 147769-93-5 (1S)-3-methyl-1-(2-piperidin-1-ylphenyl)butan-1-amine 
• 219921-93-4 (R)-3-methyl-1-(2-(1-pieridinyl)phenyl)-butylamine 

Relevant articles and documents

Preparation of 3-methyl-1 - [2 - (1-piperidinyl) phenyl] ding Yaan and the method of use of the product of

The invention discloses a method for preparing 3-methyl-1-(2-(1-piperidyl) phenyl) butyl imine and the application of the 3-methyl-1-(2-(1-piperidyl) phenyl) butyl imine. The yield of the 3-methyl-1-(2-(1-piperidyl) phenyl) butyl imine is 30 to 35 percent; the purity of the 3-methyl-1-(2-(1-piperidyl) phenyl) butyl imine is 99.0 to 99.5 percent (detected by an HPLC (high performance liquid chromatography) method); the 3-methyl-1-(2-(1-piperidyl) phenyl) butyl imine can be used as a standard substance for detecting impurities during the preparation of repaglinide amine, and can also be used for preparing high-purity repaglinide amine after subjected to catalytic hydrogenation or preparing 3-methyl-1-(2-(1-piperidyl) butanone after subjected to acidolysis; and the prepared 3-methyl-1-(2-(1-piperidyl) butanone can be used as raw material for synthesizing repaglinide amine or 3-methyl-1-(2-(1-piperidyl) phenyl) butyl imine, so as to be recycled, and raw material waste is avoided. The method is applicable to the synthesis of repaglinide amine.

Process for preparing (RS) 3-methyl-1-(2-piperidinyl phenyl) butyl amine

The Present invention relates to a process for the preparation of (RS) 3-methyl-1-(2-piperidinyl phenyl) butyl amine of formula 1. (RS) 3-Methyl-1-(2-piperidinyl phenyl butyl amine having formula 1 is an important key intermediate for the synthesis of repaglinide of formula 2 an oral hypoglycemic agent.