147779-25-7

Basic information

• Product Name: 2-BENZOYLNICOTINIC ACID
• Synonyms: 2-BENZOYLNICOTINIC ACID;2-BENZOYLPYRIDINE-3-CARBOXYLIC ACID
• CAS NO: 147779-25-7
• Molecular Formula: C₁₃H₉NO₃
• Molecular Weight: 227.22
• Mol File: 147779-25-7.mol
• Article Data: 7

Chemical Properties

• Melting Point: 186-187 °C(Solv: ligroine (8032-32-4); ethyl ether (60-29-7))
• Boiling Point: 465.4 °C at 760 mmHg
• Flash Point: 235.3 °C
• Appearance: /
• Density: 1.311 g/cm³
• Vapor Pressure: 1.84E-09mmHg at 25°C
• Refractive Index: 1.622
• PKA: 2.81±0.10(Predicted)
• CAS DataBase Reference: 2-BENZOYLNICOTINIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 2-BENZOYLNICOTINIC ACID(147779-25-7)
• EPA Substance Registry System: 2-BENZOYLNICOTINIC ACID(147779-25-7)

Safety Data

• Hazardous Substances Data: 147779-25-7(Hazardous Substances Data)

Usage

General Description

2-BENZOYLNICOTINIC ACID, also known as Benzonicotinic acid, is a chemical compound that is derived from nicotinic acid, which is a form of vitamin B3. It is commonly used as a pharmaceutical intermediate in the production of various drugs and as a starting material in the synthesis of other organic compounds. It is known for its potential biological activities, including anti-inflammatory, antioxidant, and anti-cancer properties. 2-BENZOYLNICOTINIC ACID is also used in the manufacturing of cosmetics and personal care products, as well as in the formulation of agricultural chemicals. Overall, it is a versatile compound with a wide range of applications in different industries.

InChI:InChI=1/C13H9NO3/c15-12(9-5-2-1-3-6-9)11-10(13(16)17)7-4-8-14-11/h1-8H,(H,16,17)

Upstream product

• 699-98-9 Pyridine-2,3-dicarboxylic anhydride 
• 100-59-4 phenylmagnesium chloride 
• 108-86-1 bromobenzene 
• 71-43-2 benzene 
• 88234-87-1 3-(methoxycarbonyl)pyridine-2-carboxylic acid chloride 

Downstream Products

• 942274-98-8 (3R,9bS)-2,3-dihydro-3,9b-diphenyl-oxazolo[3',2':1,2]pyrrolo[3,4-b]pyridin-5-(9bH)-one 
• 211630-12-5 5-chloro-8-phenylpyrido[2,3-d]pyridazine 
• 211630-17-0 (8-phenyl-pyrido[2,3-d]pyridazin-5-yl)-hydrazine 
• 942275-02-7 (3R,9bS)-2,3-dihydro-3,9b-biphenyl-oxazolo[3',2':1,2]pyrrolo[3,4-b](6-cyano)pyridin-5(9bH)-one 
• 942275-00-5 (3R,9bS)-2,3-dihydro-3,9b-diphenyl-oxazolo[3',2':1,2]pyrrolo[3,4-b](6-chloro)pyridin-5(9bH)-one 
• 942274-99-9 (3R,9bS)-2,3-dihydro-3,9b-diphenyl-oxazolo[3',2':1,2]-N-oxide-pyrrolo[3,4-b]pyridin-5(9bH)-one 
• 150348-51-9 8-phenylpyrido[2,3-d]pyridazin-5(6H)-one 
• 211630-02-3 8-phenyl-pyrido[2,3-d][1,2]oxazin-5-one 

Relevant articles and documents

Preparation of new axially chiral bridged 2,2′-bipyridines and pyridyl monooxazolines (pymox). Evaluation in copper(i)-catalyzed enantioselective cyclopropanation

This work reports the synthesis of new axially chiral bridged 2,2′-bipyridines 1 and pyridylmonooxazolines (pymox) 2. The potential of these new axially chiral N,N-ligands was evaluated in asymmetric catalytic cyclopropanation of styrene derivatives 22a-c with diazoesters 21a,b. While 2,2′-bipyridines 1a-c afforded the corresponding cyclopropanes 23a-f in up to 65% ee, pymoxs 2a-e gave somewhat lower enantioselectivities (up to 53% ee). Both classes of ligands produced trans-cyclopropanes 23a-f as the major isomer, although with modest diasteroselectivities (56: 44 to 78: 22). A structure-stereoselectivity relationship study of ligands 1 and 2 identified the chiral biaryl axis as being mostly responsible for the enantioselective performances of these ligands. The Royal Society of Chemistry.

Benzopyridazinone and pyridopyridazinone compounds

Benzo or pyridopyridazinones and pyridazinthiones of the formula STR1 wherein: X and Y are nitrogen or carbon, provided that at least one is carbon, and Z is oxygen or sulfur; R1 is hydrogen, lower alkyl, aryl, aralkyl, heterocyclo, heterocyclo lower-alkyl, heteroaryl, or heteroaralkyl; R2, R3, R4, R5 and R6 are independently selected from hydrogen, lower alkyl, halo, carboxy, alkoxycarbonyl, carbamoyl, lower-alkyl carbonyl, halocarbonyl, thiomethyl, trifluoromethyl, cyano or nitro; or a pharmaceutically acceptable ester, ether or salt thereof, have been found to be useful as an anti-inflammatory, antasthmatic, immunosuppressive, anti-allograft rejection, anti-graft-vs-host rejection, autoimmune disease or analgetic agent(s).

Heterocyclic compounds, their production and use as tachykinin reactor antagonists

A novel compound represented by the formula: STR1 wherein Ring A and Ring B respectively stands for an optionally substituted homo- or hetero-cyclic ring, and at least one of them stands for an optionally substituted heterocyclic ring stand; Ring C stands for an optionally substituted benzene ring; R stands for a hydrogen atom or an optionally substituted hydrocarbon residue; one of X and Y stands for --NR1 -- (R1 stands for a hydrogen atom or an optionally substituted hydrocarbon residue) or --O--, and the other stands for--CO-- or --CS--, or one of them stands for --N= and the other stands for =CR2 -- (R2 stands for a hydrogen atom, a halogen atom, an optionally substituted hydrocarbon residue, an optionally substituted amino group or an optionally substituted hydroxyl group); n denotes 1 or 2 or salts thereof which have an excellent tachykinin receptor antagonistic action and inhibitory action on plasma extravasation.