14779-18-1

Usage

Uses

Used in Pharmaceutical Industry:
2-Benzothiazolamine,7-methyl-(9CI) is used as an intermediate in the synthesis of pharmaceuticals for its structural properties and reactivity, contributing to the development of new drugs with potential therapeutic applications.
Used in Agrochemical Industry:
2-Benzothiazolamine,7-methyl-(9CI) is utilized as a building block in the production of agrochemicals, aiding in the creation of substances that can enhance crop protection and yield.
Used in Specialty Chemicals Production:
2-Benzothiazolamine,7-methyl-(9CI) serves as an intermediate in the synthesis of specialty chemicals, which are used in various industries for specific applications due to their unique properties.
Used in Advanced Material Development:
2-Benzothiazolamine,7-methyl-(9CI) is also employed in the development of novel materials and advanced technologies, taking advantage of its chemical structure and reactivity to create innovative products with improved performance.

Upstream product

• 621-40-9 (3-methylphenyl)thiourea 
• 2817-12-1 2-methyl-6-nitro-phenyl thiocyanate 
• 17356-08-0 thiourea 
• 591-24-2 3-Methylcyclohexanone 
• 1147550-11-5 ammonium thiocyanate 
• 95-53-4 o-toluidine 
• 108-44-1 1-amino-3-methylbenzene 
• 638-03-9 m-toluidine hydrochloride 

Downstream Products

• 108718-68-9 N-(7-methyl-benzothiazol-2-yl)-N'-phenyl-thiourea 
• 2942-24-7 2-Chlor-7-methyl-benzthiazol 
• 76289-34-4 β-chloropropionyl-2-amino-6-methylbenzothiazole 
• 80945-67-1 2-hydrazinyl-7-methylbenzo[d]thiazole 
• 139192-84-0 2-amino-6-methylphenyl methyl sulphide 
• 1309261-64-0 3-(7-methyl-1,3-benzothiazol-2-yl)-2-phenylquinazolin-4(3H)-one 
• 1309261-85-5 C₂₂H₁₆N₄OS 

Relevant academic research and scientific papers

Synthesis of benzo[: D] thiazole-hydrazone analogues: Molecular docking and SAR studies of potential H+/K+ ATPase inhibitors and anti-inflammatory agents

A series of new benzo[d]thiazole-hydrazones were synthesized and characterized by analytical and spectroscopic techniques. All the compounds were screened for their in vitro inhibition of H+/K+ ATPase and anti-inflammatory effects. The results revealed that compounds 6-8, 13-15, 18-20, 22, 23 and 27-30 displayed excellent inhibitory activity against H+/K+ ATPase, and their IC50 values were lower than those of the standard compound omeprazole. Compounds 2-5, 9-12, 28 and 30 exhibited better anti-inflammatory activity in comparison to the standard compound indomethacin. Studies of the structure-activity relationship (SAR) showed that electron-donating groups (OH and OCH3) favored inhibitory activity against H+/K+ ATPase, whereas electron-withdrawing groups (F, Cl, Br and NO2) favored anti-inflammatory activity, and derivatives with both electron-donating (OH and OCH3) and electron-withdrawing (Br) groups (16-18) displayed reasonable activity, whereas aliphatic analogues (24-26) exhibited less activity and heterocyclic analogues (27-30) displayed moderate activity in both biological studies. Molecular docking studies were performed for all the synthesized compounds, among which compounds 19 and 20 exhibited the highest docking scores for inhibitory activity against H+/K+ ATPase, whereas compounds 10 and 12 displayed the highest docking scores for anti-inflammatory activity.

Synthesis, SAR and molecular docking studies of benzo[d]thiazole-hydrazones as potential antibacterial and antifungal agents

A series of new benzo[d]thiazole-hydrazones analogues were synthesized and screened for their in vitro antibacterial and antifungal activities. The results revealed that compounds 13, 14, 15, 19, 20, 28 and 30 exhibited superior antibacterial potency compared to the reference drug chloramphenicol and rifampicin. Compounds 5, 9, 10, 11, 12, 28 and 30 were found to be good antifungal activity compared to the standard drug ketoconazole. A preliminary study of the structure-activity relationship (SAR) revealed that the antimicrobial activity depended on the effect of different substituents on the phenyl ring. The electron donating (OH and OCH3) groups presented in the analogues, increase the antibacterial activity (except compound 12), interestingly, while the electron withdrawing (Cl, NO2, F and Br) groups increase the antifungal activity (except compound 19 and 20). In addition, analogues containing thiophene (28) and indole (30) showed good antimicrobial activities. Whereas, aliphatic analogues (24–26) shown no activities in both bacterial and fungal stains even in high concentrations (100?μg/mL). Molecular docking studies were performed for all the synthesized compounds of which compounds 11, 19 and 20 showed the highest glide G-score.

Metal-free synthesis of 2-aminobenzothiazoles via aerobic oxidative cyclization/dehydrogenation of cyclohexanones and thioureas

A metal-free process for the synthesis of 2-aminobenzothiazoles from cyclohexanones and thioureas has been developed using catalytic iodine and molecular oxygen as the oxidant under mild conditions. Various 2-aminobenzothiazoles, 2-aminonaphtho[2,1-d]thiazoles, and 2-aminonaphtho[1,2-d] thiazoles were prepared via this method in satisfactory yields.

QSAR modeling of synthesized 3-(1,3-benzothiazol-2-yl) 2-phenyl quinazolin-4(3H)-ones as potent antibacterial agents

Present communication elicits the designing and synthesis of 3-(1,3-benzothiazol-2-yl) 2-phenyl quinazolin-4(3H)-ones as potential antibacterial agents. A number of substituted 2-amino benzothiazoles, 2-amino-5-[(E)-phenyl diazenyl] benzoic acid, and 2-phenyl-4H benzo[d] [1,3] oxazin-4-one were synthesized as the precursor substrates. The compounds were synthesized in excellent yields and the structures were corroborated on the basis of IR, 1H NMR, Mass, and elemental analysis data. These compounds were screened in vitro for their antibacterial activity against a representative panel of Gram positive and Gram negative bacteria and models were generated through quantitative structure-activity relationship (QSAR).The activity contributions due to structural and substituent effects were determined using sequential regression procedure. The antimicrobial assay data show that the synthesized compounds are found to manifest profound antimicrobial activity. Springer Science+Business Media, LLC 2011.

AZOLE DERIVATIVES AS WTN PATHWAY INHIBITORS

The present invention relates to new compounds of formula I, to processes for their preparation, to pharmaceutical formulations containing such compounds and to their use in therapy. Such compounds find particular use in the treatment and/or prevention of conditions or diseases which are affected by over-activation of signaling in the Wnt pathway. For example, these may be used in preventing and/or retarding proliferation of tumor cells, for example carcinomas such as colon carcinomas.