14779-18-1

Basic information

• Product Name: 2-Benzothiazolamine,7-methyl-(9CI)
• Synonyms: 7-Methylbenzo[d]thiazol-2-aMine;2-Benzothiazolamine,7-methyl-(9CI)
• CAS NO: 14779-18-1
• Molecular Formula: C₈H₈N₂S
• Molecular Weight: 164.22752
• Product Categories: BENZOTHIAZOLE
• Mol File: 14779-18-1.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• CAS DataBase Reference: 2-Benzothiazolamine,7-methyl-(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Benzothiazolamine,7-methyl-(9CI)(14779-18-1)
• EPA Substance Registry System: 2-Benzothiazolamine,7-methyl-(9CI)(14779-18-1)

Safety Data

• Hazardous Substances Data: 14779-18-1(Hazardous Substances Data)

Usage

General Description

2-Benzothiazolamine, 7-methyl-(9CI) is a chemical compound with the molecular formula C9H9NS. It belongs to the benzothiazole class of chemicals and is characterized by a benzene ring fused to a thiadiazole ring. The "7-methyl" in its name indicates the presence of a methyl group at the seventh carbon position of the benzothiazolamine molecule. 2-Benzothiazolamine,7-methyl-(9CI) is used in organic synthesis and pharmaceutical research as it serves as an important building block for the synthesis of various biologically active compounds. Its structural properties and reactivity make it a valuable intermediate for the production of pharmaceuticals, agrochemicals, and specialty chemicals. Additionally, it has applications in the development of novel materials and advanced technologies.

Upstream product

• 621-40-9 (3-methylphenyl)thiourea 
• 1147550-11-5 ammonium thiocyanate 
• 108-44-1 1-amino-3-methylbenzene 
• 17356-08-0 thiourea 
• 591-24-2 3-Methylcyclohexanone 
• 95-53-4 o-toluidine 
• 638-03-9 m-toluidine hydrochloride 
• 2817-12-1 2-methyl-6-nitro-phenyl thiocyanate 

Downstream Products

• 108718-68-9 N-(7-methyl-benzothiazol-2-yl)-N'-phenyl-thiourea 
• 2942-24-7 2-Chlor-7-methyl-benzthiazol 
• 80945-67-1 2-hydrazinyl-7-methylbenzo[d]thiazole 
• 139192-84-0 2-amino-6-methylphenyl methyl sulphide 
• 1309261-64-0 3-(7-methyl-1,3-benzothiazol-2-yl)-2-phenylquinazolin-4(3H)-one 
• 1309261-85-5 C₂₂H₁₆N₄OS 
• 76289-34-4 β-chloropropionyl-2-amino-6-methylbenzothiazole 

Relevant articles and documents

Synthesis of benzo[: D] thiazole-hydrazone analogues: Molecular docking and SAR studies of potential H+/K+ ATPase inhibitors and anti-inflammatory agents

A series of new benzo[d]thiazole-hydrazones were synthesized and characterized by analytical and spectroscopic techniques. All the compounds were screened for their in vitro inhibition of H+/K+ ATPase and anti-inflammatory effects. The results revealed that compounds 6-8, 13-15, 18-20, 22, 23 and 27-30 displayed excellent inhibitory activity against H+/K+ ATPase, and their IC50 values were lower than those of the standard compound omeprazole. Compounds 2-5, 9-12, 28 and 30 exhibited better anti-inflammatory activity in comparison to the standard compound indomethacin. Studies of the structure-activity relationship (SAR) showed that electron-donating groups (OH and OCH3) favored inhibitory activity against H+/K+ ATPase, whereas electron-withdrawing groups (F, Cl, Br and NO2) favored anti-inflammatory activity, and derivatives with both electron-donating (OH and OCH3) and electron-withdrawing (Br) groups (16-18) displayed reasonable activity, whereas aliphatic analogues (24-26) exhibited less activity and heterocyclic analogues (27-30) displayed moderate activity in both biological studies. Molecular docking studies were performed for all the synthesized compounds, among which compounds 19 and 20 exhibited the highest docking scores for inhibitory activity against H+/K+ ATPase, whereas compounds 10 and 12 displayed the highest docking scores for anti-inflammatory activity.

Metal-free synthesis of 2-aminobenzothiazoles via aerobic oxidative cyclization/dehydrogenation of cyclohexanones and thioureas

A metal-free process for the synthesis of 2-aminobenzothiazoles from cyclohexanones and thioureas has been developed using catalytic iodine and molecular oxygen as the oxidant under mild conditions. Various 2-aminobenzothiazoles, 2-aminonaphtho[2,1-d]thiazoles, and 2-aminonaphtho[1,2-d] thiazoles were prepared via this method in satisfactory yields.

AZOLE DERIVATIVES AS WTN PATHWAY INHIBITORS

The present invention relates to new compounds of formula I, to processes for their preparation, to pharmaceutical formulations containing such compounds and to their use in therapy. Such compounds find particular use in the treatment and/or prevention of conditions or diseases which are affected by over-activation of signaling in the Wnt pathway. For example, these may be used in preventing and/or retarding proliferation of tumor cells, for example carcinomas such as colon carcinomas.