26956-44-5

Basic information

• Product Name: 2-METHYLFURO[3,2-C]PYRIDIN-4-OL
• Synonyms: 2-METHYLFURO[3,2-C]PYRIDIN-4-OL;2-methylfuro[3,2-c]pyridin-4(5H)-one;2-methyl-5H-furo[3,2-c]pyridin-4-one
• CAS NO: 26956-44-5
• Molecular Formula: C₈H₇NO₂
• Molecular Weight: 149.15
• Mol File: 26956-44-5.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 382.7±42.0°C at 760 mmHg (Cal.) ref.
• Flash Point: 185.2±27.9°C (Cal.) ref.
• Appearance: /
• Density: 1.2±0.1g/cm3 (Cal.) ref.
• PKA: 12.77±0.20(Predicted)
• CAS DataBase Reference: 2-METHYLFURO[3,2-C]PYRIDIN-4-OL(CAS DataBase Reference)
• NIST Chemistry Reference: 2-METHYLFURO[3,2-C]PYRIDIN-4-OL(26956-44-5)
• EPA Substance Registry System: 2-METHYLFURO[3,2-C]PYRIDIN-4-OL(26956-44-5)

Safety Data

• Hazardous Substances Data: 26956-44-5(Hazardous Substances Data)

Usage

General Description

2-METHYLFURO[3,2-C]PYRIDIN-4-OL is a chemical compound with a molecular formula of C9H7NO. It is a heterocyclic compound that consists of a furan ring fused to a pyridine ring, with a hydroxyl group attached to the pyridine ring at the 4 position and a methyl group at the 2 position. 2-METHYLFURO[3,2-C]PYRIDIN-4-OL is used in the field of organic synthesis and pharmaceutical research. It possesses potential biological and pharmacological activities and is being studied for its potential medicinal properties. Its structural features make it an interesting candidate for further research in drug discovery and development.

Upstream product

• 84050-23-7 3-(5-methyl-furan-2-yl)-acryloyl chloride 
• 620-02-0 5-Methylfurfural 
• 1585965-57-6 C₈H₇N₃O₂ 
• 31270-83-4 2-methylfuro<3,2-c>pyridine 
• 220992-24-5 2-methylfuro<3,2-c>pyridine N-oxide 
• 14779-25-0 3-(5-methylfuran-2-yl) acrylic acid 

Downstream Products

• 1472655-11-0 C₂₉H₂₇NO₆S 
• 1472655-10-9 C₂₉H₂₇NO₇ 

Relevant articles and documents

A METHOD FOR THE SITE-SPECIFIC ENZYMATIC LABELLING OF NUCLEIC ACIDS IN VITRO BY INCORPORATION OF UNNATURAL NUCLEOTIDES

Provided herein are analogs of unnatural nucleotides bearing predominantly hydrophobic nucleobase analogs that form unnatural base pairs during DNA polymerase- mediated replication of DNA or RNA polymerase-mediated transcription of RNA. In this manner, the unnatural nucleobases can be introduced in a site-specific way into oligonucleotides (single or double stranded DNA or RNA), where they can provide for site-specific cleavage, or can provide a reactive linker than can undergo functionalization with a cargo -bearing reagent by means of reaction with a primary amino group or by means of click chemistry with an alkyne group of the unnatural nucleobase linker.

Furopyridines. XXVII. Reactions of 2-methyl and 2-cyano derivatives of furo[2,3-b]-, -[3,2-b]-, - [2,3-c]- and -[3,2-c]pyridine

Bromination of 2-methylfuropyridines 1a-d-Me gave the 3-bromo derivatives 2a-d, while the 2-cyano compounds 1a-d-CN resulted in the recovery of the starting compounds. Nitration of 1a-d-Me and 1a-d-CN did not yield the corresponding nitro derivative, except for 1-c-CN giving 3-nitro derivative 3c in 7% yield. N-Oxidation of 1a-d-Me and 1b-d-CN with m- chloroperbenzoic acid yielded the N-oxides 4a-d-Me and 4b-d-CN, whereas 1a- CN did not afford the N-oxide. Cyanation of N-oxides 4a-d-Me and 4b-d-CN with trimethylsilyl cyanide gave the corresponding α-cyanopyridine compounds 5a- d-Me and 5b-d-CN. Chlorination of 4a-d-Me and 4b-d-CN with phosphorus oxychloride also gave the α-chloropyridine compounds 6b-d-Me and 6b-d-CN, accompanying formation of γ-chloropyridine 6a-Me, 6'b-Me and 6'b-CN, β- chloropyridine 6(b)-CN, and α'-chloropyridine derivatives 6'c-Me and 6'c- CN. Acetoxylation of 4a-d-Me and 4b-d-CN with acetic anhydride yielded α- acetoxypyridine compounds 7a-Me and 7b-CN, pyridone compounds 11d-Me, 11c-CN and 11d-CN, 3-acetoxy compounds 8, 9b, 9c, and 2-acetoxymethyl derivatives 10b and 10c.