147807-80-5Relevant academic research and scientific papers
Total synthesis of the isoquinolinium metabolite ETM-204 of Trabectidin
Breinbauer, Rolf,Gissing, Simon,Lembacher-Fadum, Christian,Pour, Georg
, (2021/10/23)
Ecteinascidin-743 (Trabectidin, Trabectedin, Yondelis) is a synthetically obtained pharmaceutical drug originally isolated from a marine tunicate. Trabectedin is used for the chemotherapy of soft-tissue sarcoma and ovarian cancer. Th
Total synthesis of the β-adrenergic receptor antagonist, the tetrahydroisoquinoline MY336-a and its epimer
Kaufman, Teodoro S.
, p. 2497 - 2505 (2007/10/03)
The first total synthesis of the novel β-adrenergic receptor antagonist MY336-a 1 and its epimer 2 has been achieved from 2,3-dimethoxytoluene, by Jackson cyclisation of N-benzyl-N-tosylamido acetals, Lewis acid-mediated addition of silicon-based nucleoph
Studies on the Natural β-Adrenergic Receptor Antagonist MY336-a: Synthesis of a 3-Dehydroxymethyl Analogue
Kaufman, Teodoro S.
, p. 403 - 404 (2007/10/02)
The preparation of a polysubstituted tetrahydroisoquinoline, which lacks only the 3-CH2OH group of MY336-a, is described.
