18102-31-3Relevant articles and documents
Tandem Oxidative Phenol Dearomatization/Formal [3+2] Annulation Protocol en Route to Highly Functionalized Benzothiophenes
Chittimalla, Santhosh Kumar,Bandi, Chennakesavulu
, p. 1051 - 1056 (2017)
A new strategy for the synthesis of benzothiophenes through formal [3+2] annulation of sulfanylacetaldehyde and cyclohexa-2,4-dien-1-one monoketals has been developed. This approach relies on the ease of aromatization of tetrahydrobenzothiophenone derivatives prepared by the aforementioned protocol. Given the ready accessibility of various substituted cyclohexa-2,4-dien-1-one monoketals, a range of benzothiophene derivatives became available.
Total synthesis of the isoquinolinium metabolite ETM-204 of Trabectidin
Breinbauer, Rolf,Gissing, Simon,Lembacher-Fadum, Christian,Pour, Georg
, (2021/10/23)
Ecteinascidin-743 (Trabectidin, Trabectedin, Yondelis) is a synthetically obtained pharmaceutical drug originally isolated from a marine tunicate. Trabectedin is used for the chemotherapy of soft-tissue sarcoma and ovarian cancer. Th
SUBSTITUTED-PYRIDINYL COMPOUNDS AND USES THEREOF
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Page/Page column 37; 91-92, (2020/01/10)
The present application relates generally to compounds useful for the treatment and/or enhancement of cognitive dysfunction and negative symptoms associated with CNS disorders where the circuitry involving fast spiking PV+ interneurons and the production of cortical gamma oscillations is disrupted. The subject disclosure enables the manufacture of medicaments as well as compositions containing same for use in methods of therapy and prophylaxis of cognitive dysfunction and negative symptoms.