14786-25-5

Basic information

• Product Name: (RS)-α-methylbenzenemethyl 4-nitrobenzoate
• CAS NO: 14786-25-5
• Molecular Weight: 271.273
• Mol File: 14786-25-5.mol
• Article Data: 9

Chemical Properties

• CAS DataBase Reference: (RS)-α-methylbenzenemethyl 4-nitrobenzoate(CAS DataBase Reference)
• NIST Chemistry Reference: (RS)-α-methylbenzenemethyl 4-nitrobenzoate(14786-25-5)
• EPA Substance Registry System: (RS)-α-methylbenzenemethyl 4-nitrobenzoate(14786-25-5)

Safety Data

• Hazardous Substances Data: 14786-25-5(Hazardous Substances Data)

Upstream product

• 98-85-1 1-Phenylethanol 
• 619-80-7 4-nitrobenzamide 
• 62-23-7 4-nitro-benzoic acid 
• 100-41-4 ethylbenzene 
• 99-99-0 1-methyl-4-nitrobenzene 
• 122-04-3 4-nitro-benzoyl chloride 

Relevant articles and documents

Preparation of alkylated compounds using the trialkylphosphate

[Problem] trialkylphosphate strong base used reaction agent, a carboxylic acid, a ketone, an aldehyde, amine, amide, thiol, ester or Grignard reagent to a variety of substrates, and/or high efficiency to generate a highly stereoselective alkylation reaction, the alkylated compounds capable of producing new means. [Solution] was used as the alkylating agent in the alkylation of compound trialkylphosphate, strongly basic reaction production use. [Drawing] no

Regio- And Stereoselective (S N2) N -, O -, C - And S -Alkylation Using Trialkyl Phosphates

Bimolecular nucleophilic substitution (S N 2) is one of the most well-known fundamental reactions in organic chemistry to generate new molecules from two molecules. In principle, a nucleophile attacks from the back side of an alkylating agent having a suitable leaving group, most commonly a halide. However, alkyl halides are expensive, very harmful, toxic and not so stable, which makes them problematic for laboratory use. In contrast, trialkyl phosphates are inexpensive, readily accessible and stable at room temperature, under air, and are easy to handle, but rarely used as alkylating agents in organic synthesis. Here, we describe a mild, straightforward and powerful method for nucleophilic alkylation of various N -, O -, C - and S -nucleophiles using readily available trialkyl phosphates. The reaction proceeds smoothly in excellent yield, and quantitative yield in many cases, and covers a wide range of substrates. Further, the rare stereoselective transfer of secondary alkyl groups has been achieved with inversion of configuration of chiral centers (up to 98% ee).

Easy access to benzylic esters directly from alkyl benzenes under metal-free conditions

An efficient metal free protocol has been developed for the synthesis of benzylic esters via a cross dehydrogenative coupling (CDC) involving alkylbenzene(s) as a self- or as a cross-coupling partner(s) via the intermediacy of Ar-COOH and the benzylic carbocation obtained from the other half of the alkylbenzene; both symmetrical as well as unsymmetrical esters can be prepared using Bu4NI and TBHP. The Royal Society of Chemistry.