147875-53-4Relevant academic research and scientific papers
Mechanism and inhibition of inositol monophosphatase
Baker, Raymond,Broughton, Howard B.
, p. 337 - 340 (1996)
The design and synthesis of inhibitors of inositol monophosphatase (IMPase, B.C. 3.1.3.25) based on natural substrates and lead compounds discovered by screening is discussed. The physiologically relevant form of the enzyme and a likely mechanism have been deduced from structure-activity relationships, site-directed mutagenesis experiments, X-ray crystallography and molecular modelling.
