6195-80-8

Upstream product

• 13246-46-3 2,4-dibenzyloxybenzaldehyde 
• 1774-47-6 trimethylsulfoxonium iodide 
• 85716-45-6 1L-(2,4,5/3)-2,3,4-Tri-O-benzyl-2,3,4,5-tetrahydroxy-1-cyclohexanon 
• 30485-15-5 (+/-)-4,5,6-Tribenzyloxycyclohex-2-enon 
• 6383-01-3 (+/-)-1-O-p-toluenesulfonyl-3,4,5,6-tetra-O-benzyl-myo-inositol 
• 533-73-3 1,2,4-Trihydroxybenzene 
• 100-39-0 benzyl bromide 
• 85798-11-4 (4S,5R,6S)-4,5,6-tris-benzyloxycyclohex-2-en-1-one 
• 1338920-35-6 4,5,6-tri-O-benzyl-1,3-O-methylidenemyoinositol 
• 1338649-71-0 4,5,6-tri-O-benzyl-1,3-O-methylidene-2-O-tosylmyoinositol 
• 1338649-72-1 4,5,6-tri-O-benzyl-2-O-tosylmyoinositol 
• 155155-66-1 C₂₇H₂₆O₄ 
• 1338720-16-3 ((5-bromo-2-methylbenzyl)oxy)(tert-butyl)dimethylsilane 
• 29847-13-0 (±)-1,4,5,6-tetra-O-benzyl-2,3-O-isopropylidene-myo-inositol 

Downstream Products

• 6383-02-4 2,4-bis(benzyloxy)-1-methoxybenzene 
• 147875-53-4 (2,4-Bis-benzyloxy-phenoxymethyl)-phosphonic acid diethyl ester 
• 622390-71-0 [4,6-bis-benzyloxy-2-methoxymethoxy-3-(3-methyl-but-2-enyl)-phenyl]-(2,4-bis-benzyloxy-5-methoxy-phenyl)-methanol 
• 622390-85-6 [4,6-bis-benzyloxy-2-methoxymethoxy-3-(3-methyl-but-2-enyl)-phenyl]-(2,4-bis-benzyloxy-5-methoxy-phenyl)-methanone 
• 622390-73-2 [4,6-dihydroxy-2-methoxymethoxy-3-(3-methyl-but-2-enyl)-phenyl]-(2,4-dihydroxy-5-methoxy-phenyl)-methanone 
• 622390-57-2 1,5-Bis-benzyloxy-2-bromo-4-methoxy-benzene 
• 426820-51-1 2,4-bis-benzyloxy-5-bromo-phenol 
• 251921-27-4 1-O-(2,3,4,6-tetra-O-acetyl-beta-D-glucopyranosyl)-2,4-dibenzyloxybenzene 
• 170282-09-4 ethyl (2,4-dibenzyloxyphenoxy)acetate 

Relevant academic research and scientific papers

Total Synthesis of Two Glycosylated Stilbenes, Oxyresveratrol 2-O-β- d -Glucopyranoside and 2,3,5,4′-Tetrahydroxystilbene 2-O-β- d -Glucopyranoside

Glycosylated stilbenes are biologically active secondary metabolites of plants and have the potential to alleviate a broad range of human diseases. However, some of these compounds are not naturally abundant, and thus the synthesis of such molecules is de

Tyrosinase inhibitor

PROBLEM TO BE SOLVED: To provide a new resorcinol derivative, and further, to provide a new tyrosinase activity inhibitor composed of the resorcinol derivative. SOLUTION: There are provided the resorcinol derivative, represented by formula 1, and th

IRE-1α INHIBITORS

PROBLEM TO BE SOLVED: To provide compounds which directly inhibit inositol requiring enzyme 1 (IRE-1α activity) in vitro, prodrugs, and pharmaceutically acceptable salts thereof. SOLUTION: The present invention provides a compound represented by formula (A) [R3 and R4 are H or the like; Q5-Q8, together with the benzene ring to which they are attached, form a benzofused ring, where at least one of Q5-Q8 is a heteroatom selected from N, O, and S. COPYRIGHT: (C)2016,JPOandINPIT

A formal synthesis of valiolamine from myo-inositol

An efficient formal synthesis of racemic valiolamine starting from readily available myo-inositol is reported. In all the synthetic steps only one regioisomer is formed, which circumvents laborious purification of products. Regioselective benzylation of myo-inositol orthoformate, super-hydride mediated deoxygenation of a cyclitol derivative and stereoselective addition of dichloromethyllithium to an inosose are the key reactions in the synthesis.

The stereoselective syntheses of 1-aryl-1,6-dideoxyinositol derivatives

This Letter describes the first report of a highly stereoselective synthesis of triethereal cyclohexanones via copper(I) mediated 1,4-addition of organometallic reagents to glucose-derived triethereal cyclohexenone. The cyclohexanones generated can be red

A new structural class of S-adenosylhomocysteine hydrolase inhibitors

Effective inhibitors of S-adenosylhomocysteine hydrolase hold promise towards becoming useful therapeutic agents. Since most efforts have focused on the development of nucleoside analog inhibitors, issues regarding bioavailability and selectivity have bee

Transformation of glucose into a novel carbasugar amino acid dipeptide isostere

The synthesis of a novel carbasugar amino acid (15), starting from D-glucose and using the Ferrier rearrangement as a key step, is reported. Compound 15 is implemented as dipeptide isostere in the synthesis of a Leu-enkephalin analog. Copyright Taylor & F

Biological activities of α-mangostin derivatives against acidic sphingomyelinase

Deprenyl and benzofenone-type congeners of α-mangostin 1 have been synthesized to understand their role for the inhibitory activity against sphingomyelinase (SMase). While removal of the prenyl group of the right side (11 and 12) caused loss of the selectivity between ASMase (acidic sphingomyelinase) and NSMase (neutral sphingomyelinase), the prenyl group of the left side appeared to increase the inhibitory activities (16 and 17).

The first direct synthesis of α-mangostin, a potent inhibitor of the acidic sphingomyelinase

A total synthesis of α-mangostin 1a has been achieved. The key cyclization reaction to construct the xanthone framework was undertaken by employing the PPh3-CCl4 conditions. The inhibitory activities of 1a and the benzophenone intermediate 16 against the acidic sphingomyelinase were discussed.

Substituted phenyl compounds

Compounds of formula (I) are described wherein R1is hydrogen, -(lower alkyl)q(CO2R6or OH), —CN, —C(R7)═NOR8, NO2, —O(lower alkyl)R9, —C≡C—R10, —CR11═C(R12)(R13), —C(═O)CH2C(═O)CO2H, —CO(R14), alkylthio, alkylsulphinyl, alkylsulphonyl, carbamoyl, thiocarbamoyl, substituted carbamoyl, substituted thiocarbamoyl, sulphamoyl or an optionally substituted nitrogen-containing ring, m, n, o and p are independently zero or 1 and R2, R3, R4and R5are various groups; and physiologically acceptable salts, N-oxides and prodrugs thereof. The compounds have endothelin antagonist activity and are useful as pharmaceuticals.