Mechanism and inhibition of inositol monophosphatase

Article abstract of DOI:10.1080/10426509608545159

The design and synthesis of inhibitors of inositol monophosphatase (IMPase, B.C. 3.1.3.25) based on natural substrates and lead compounds discovered by screening is discussed. The physiologically relevant form of the enzyme and a likely mechanism have been deduced from structure-activity relationships, site-directed mutagenesis experiments, X-ray crystallography and molecular modelling.

Full text of DOI:10.1080/10426509608545159

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Phosphorus, Sulfur, and Silicon and
the Related Elements
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Mechanism and Inhibition of
Inositol Monophosphatase
Raymond Baker & Howard B. Broughton
a Merck Sharp and Dohme Neuroscience Research Centre ,
Eastwick Road, HARLOW, Essex. CM20 2QR, UK
b Merck Sharp and Dohme Neuroscience Research Centre ,
Eastwick Road, HARLOW, Essex. CM20 2QR, UK
Published online: 06 Aug 2008.
To cite this article: Raymond Baker & Howard B. Broughton (1996) Mechanism and
Inhibition of Inositol Monophosphatase, Phosphorus, Sulfur, and Silicon and the Related
Elements, 109:1-4, 337-340
To link to this article: http://dx.doi.org/10.1080/10426509608545159
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