Phosphorus, Sulfur and Silicon and the Related Elements p. 337 - 340 (1996)
Update date:2022-08-06
Topics:
Baker, Raymond
Broughton, Howard B.
The design and synthesis of inhibitors of inositol monophosphatase (IMPase, B.C. 3.1.3.25) based on natural substrates and lead compounds discovered by screening is discussed. The physiologically relevant form of the enzyme and a likely mechanism have been deduced from structure-activity relationships, site-directed mutagenesis experiments, X-ray crystallography and molecular modelling.
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