147930-86-7Relevant articles and documents
Synthesis and analgesic effects of kyotorphin-steroid linkers
Wang, Chao,Zhao, Ming,Yang, Jian,Peng, Shiqi
, p. 811 - 815 (2001)
Kyotorphin (KTP, H-Tyr-Arg-OH) was covalently bonded with hydrocortisone or estrone to form the corresponding hydrocortisone-21-O-yl-succinyl-Tyr-ArgOH or estrone-3-O-yl-acyl-Tyr-Arg-OH. Their analgesic activities were investigated using the tail flick test. The potency of the two linkers were significantly higher than that of KTP and the mixture of KTP and hydrocortisone or estrone in the CNS and/or the periphery administration. Copyright