62023-63-6

Basic information

• Product Name: 2R, 3S, 3 AMINO 2 HYDROXY 4 PHENYL BUTONIC ACID
• Synonyms: 2R, 3S, 3 AMINO 2 HYDROXY 4 PHENYL BUTONIC ACID;(2R,3S)-2-Hydroxy-3-amino-4-phenylbutanoic acid;(2R,3S)-2-Hydroxy-3-amino-4-phenylbutyric acid;(2R,3S)-3-Amino-2-hydroxy-4-phenylbutyric acid;Phenylnorstatine;(2R,3S)-AHPA
• CAS NO: 62023-63-6
• Molecular Formula: C₁₀H₁₃NO₃
• Molecular Weight: 195.21512
• Mol File: 62023-63-6.mol
• Article Data: 9

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2R, 3S, 3 AMINO 2 HYDROXY 4 PHENYL BUTONIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 2R, 3S, 3 AMINO 2 HYDROXY 4 PHENYL BUTONIC ACID(62023-63-6)
• EPA Substance Registry System: 2R, 3S, 3 AMINO 2 HYDROXY 4 PHENYL BUTONIC ACID(62023-63-6)

Safety Data

• Hazardous Substances Data: 62023-63-6(Hazardous Substances Data)

Usage

General Description

The chemical 2R, 3S, 3 amino 2 hydroxy 4 phenyl butonic acid is an organic compound with the molecular formula C10H13NO3. It is a chiral molecule with two stereocenters, and the 2R, 3S configuration indicates the stereochemistry of the molecule. The compound contains an amino group, a hydroxy group, and a phenyl group, along with a 4-carbon backbone. It is commonly used as an intermediate in the synthesis of pharmaceuticals and other organic compounds. The presence of the amino and hydroxy groups make it a versatile building block for the synthesis of a variety of compounds.

Upstream product

• 62023-60-3 (2R,3S)-N-(benzyloxycarbonyl)-3-amino-2-hydroxy-4-phenylbutanoic acid 
• 118970-36-8 (2R,3S)-3-(dibenzylamino)-2-hydroxy-4-phenylbutanenitrile 
• 195510-33-9 (2R,3S)-3-(dibenzylamino)-2-hydroxy-4-phenylbutanoic acid 
• 73845-40-6 methyl trans-2,3-epoxy-4-phenylbutanoate 
• 63158-17-8 methyl (E)-4-phenyl-2-butenoate 
• 136354-01-3 N-methoxycarbonyl-1-methoxy-2-phenylethylamine 
• 75443-87-7 methyl DL-erythro-3-amino-2-hydroxy-4-phenylbutanoate 
• 6540-96-1 2-benzyl-4-pentenoic acid 
• 501-52-0 3-Phenylpropionic acid 
• 73845-40-6 methyl cis-2,3-epoxy-4-phenylbutanoate 
• 34541-75-8 methyl (Z)-4-phenyl-2-butenoate 
• 75414-66-3 methyl threo-3-hydroxy-2-tosyloxy-4-phenylbutanoate 
• 75414-69-6 methyl threo-2,3-dihydroxy-4-phenylbutanoate 
• 37779-49-0 methyl 3-oxo-4-phenylbutanoate 

Downstream Products

• 176751-63-6 (2S,3S)-3-(ethoxycarbonyl)amino-2-hydroxy-4-phenylbutyric acid 

Relevant articles and documents

N -Boc amines to oxazolidinones via Pd(II)/bis-sulfoxide/br?nsted acid Co-catalyzed allylic C-H oxidation

A Pd(II)/bis-sulfoxide/Br?nsted acid catalyzed allylic C-H oxidation reaction for the synthesis of oxazolidinones from simple N-Boc amines is reported. A range of oxazolidinones are furnished in good yields (avg 63%) and excellent diastereoselectivities (avg 15:1) to furnish products regioisomeric from those previously obtained using allylic C-H amination reactions. Mechanistic studies suggest the role of the phosphoric acid is to furnish a Pd(II)bis-sulfoxide phosphate catalyst that promotes allylic C-H cleavage and π-allylPd functionalization with a weak, aprotic oxygen nucleophile and to assist in catalyst regeneration.

PROCESSES FOR PRODUCING OXAZOLIDINONE DERIVATIVE OF BETA-HYDROXYETHYLAMINE COMPOUND AND FOR PRODUCING BETA-HYDROXYETHYLAMINE COMPOUND

The present invention provides a process of starting from N-alkoxycarbonyl-ethylamine compounds having a leaving group at the β-position to prepare oxazolidinone derivatives of β-hydroxyethylamine compounds having an inverted steric configuration at the β

Stereoselective cyanation of chiral α-amino aldehydes by reaction with Nagata's reagent: A route to enantiopure β-amino-α-hydroxy acids

Chiral α-dibenzylamino aldehydes react with diethylaluminum cyanide leading to anti-β-dibenzylamino-α-hydroxycyanides as the major diastereoisomers in good yields and diastereomeric excesses. Hydrolysis of the nitrile derivatives allows the synthesis of enantiopure β-amino-α-hydroxy acids.