62023-63-6

Usage

Uses

Used in Pharmaceutical Industry:
2R, 3S, 3 amino 2 hydroxy 4 phenyl butonic acid is used as a key intermediate in the synthesis of various pharmaceuticals for its ability to be incorporated into complex molecular structures. The presence of the amino and hydroxy groups allows for the formation of amide and ester linkages, facilitating the creation of diverse drug candidates with potential therapeutic applications.
Used in Organic Synthesis:
In the field of organic synthesis, 2R, 3S, 3 amino 2 hydroxy 4 phenyl butonic acid serves as a valuable building block for the creation of a wide range of organic compounds. Its functional groups enable chemists to perform various reactions, such as condensation, substitution, and rearrangement, to synthesize target molecules with specific properties and applications in different industries.

Upstream product

• 62023-60-3 (2R,3S)-N-(benzyloxycarbonyl)-3-amino-2-hydroxy-4-phenylbutanoic acid 
• 62023-57-8 (S)-1-(2'-benzyloxycarbonylamino-3'-phenylpropanoyl)-3,5-dimethylpyrazole 
• 147976-17-8 (4S,5R)-4-benzyl-2-oxazolidinone-5-carboxylic acid methyl ester 
• 393516-55-7 (S)-1,1-dibromo-3-(ethoxycarbonyl)amino-2-oxo-4-phenylbutane 
• 195510-33-9 (2R,3S)-3-(dibenzylamino)-2-hydroxy-4-phenylbutanoic acid 
• 75523-28-3 5-benzyl-1,2-dihydropyrazol-3-one 
• 501-52-0 3-Phenylpropionic acid 
• 6540-96-1 2-benzyl-4-pentenoic acid 
• 62-50-0 Ethyl methanesulfonate 
• 118970-36-8 (2R,3S)-3-(dibenzylamino)-2-hydroxy-4-phenylbutanenitrile 
• 123054-12-6 (2S)-N,N-dibenzylphenylalaninal 
• 114671-12-4 (4S,5S)-5-ethenyl-4-phenylmethyloxazolidin-2-one 
• 869487-56-9 (4S,5R)-4-Benzyl-5-(1,2-dihydroxy-ethyl)-oxazolidin-2-one 
• 289911-81-5 (4S,5R)-4-benzyl-2-oxo-5-oxazolidinecarboxylic acid 

Downstream Products

• 176751-63-6 (2S,3S)-3-(ethoxycarbonyl)amino-2-hydroxy-4-phenylbutyric acid 

Relevant academic research and scientific papers

N -Boc amines to oxazolidinones via Pd(II)/bis-sulfoxide/br?nsted acid Co-catalyzed allylic C-H oxidation

A Pd(II)/bis-sulfoxide/Br?nsted acid catalyzed allylic C-H oxidation reaction for the synthesis of oxazolidinones from simple N-Boc amines is reported. A range of oxazolidinones are furnished in good yields (avg 63%) and excellent diastereoselectivities (avg 15:1) to furnish products regioisomeric from those previously obtained using allylic C-H amination reactions. Mechanistic studies suggest the role of the phosphoric acid is to furnish a Pd(II)bis-sulfoxide phosphate catalyst that promotes allylic C-H cleavage and π-allylPd functionalization with a weak, aprotic oxygen nucleophile and to assist in catalyst regeneration.

Highly stereoselective intramolecular SN2′ cyclization yielding chiral oxazolidin-2-ones: General route to α-hydroxy-β-amino acids

Intramolecular nucleophilic attack onto allylsulfonates promoted by silica gel acting as an acid catalyst provides expedient stereoselective access to 4,5-difunctionalized oxazolidin-2-ones. Precursors were prepared efficiently from enantiopure α-amino ac

PROCESSES FOR PRODUCING OXAZOLIDINONE DERIVATIVE OF BETA-HYDROXYETHYLAMINE COMPOUND AND FOR PRODUCING BETA-HYDROXYETHYLAMINE COMPOUND

The present invention provides a process of starting from N-alkoxycarbonyl-ethylamine compounds having a leaving group at the β-position to prepare oxazolidinone derivatives of β-hydroxyethylamine compounds having an inverted steric configuration at the β

PROCESS FOR PRODUCING 3-AMINO-2-HYDROXYPROPIONIC ACID DERIVATIVES

The present invention provides a process for preparing 3-amino-2-hydroxypropionic acid derivatives (1) which does not use dangerous reagents, is economically advantageous, and is suitable for an industrial production, which process comprises:treating N-protected-3-amino-2-hydroxypropionic acid derivatives (2) having a steric configuration at 2-position carbon reverse to that of derivatives (1) with a leaving group-introducing agent to convert into N-protected-3-aminopropionic acid derivatives (3),then treating the derivatives with a basic substance to convert into substituted-3-amino-2-hydroxypropionic acid derivatives (4) having an inverted steric configuration at 2-position carbon,and then converting the derivatives into 3-amino-2-hydroxypropionic acid derivatives (1).

Stereoselective cyanation of chiral α-amino aldehydes by reaction with Nagata's reagent: A route to enantiopure β-amino-α-hydroxy acids

Chiral α-dibenzylamino aldehydes react with diethylaluminum cyanide leading to anti-β-dibenzylamino-α-hydroxycyanides as the major diastereoisomers in good yields and diastereomeric excesses. Hydrolysis of the nitrile derivatives allows the synthesis of enantiopure β-amino-α-hydroxy acids.

Process for producing norstatin derivatives

This invention to provide a process for producing an optically active threo-phenylnorstatin derivative which does not require a toxic cyanating agent or a costly reagent, or a complicated procedure, and can be practiced on a commercial scale. This inventi

Process for producing optically active cyanohydrins

An optically active cyanohydrin represented by the following general formula (1): STR1 wherein each of R1 and R2 is a hydrogen atom or an amino-protecting group, and the configurations relating to the carbon atoms at the *2-position and *3-position are as

Diastereoselective Synthesis of 3-Amino-2-Hydroxyalkanoic Acid Derivatives

Both diastereomers of 3-amino-2-hydroxyalkanoic acid derivatives were synthesized selectively by LDA-induced reaction of N-methoxycarbonyl-1-methoxyamines with O-protected N,N-dimethylglycolamides.The inversion of the diastereoselectivity was highly achieved by 1) selecting the O-protecting groups and 2) the addition of Ti(OPr-i)4.